Gamma-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE

Advances in Experimental Medicine and Biology
Michael E BoultonYadan Zhang

Abstract

In conclusion, gamma-secretase is expressed in both retinal microvascular endothelial cells and RPE cells and is able to elicit regulated intramembrane proteolysis of VEGFR1. Furthermore, gamma-secretase regulates the translocation of the intracellular domain of VEGFR1 as well as full length VEGFR1 in both cell types. Gamma-secretase is clearly able to act as a potent negative regulators of VEGFR2 induced in vitro angiogenesis but its role in the RPE has yet to be elucidated. We conclude that gamma-secretase may offer a therapeutic target for the treatment of both retinal and choroidal neovascularization.

Citations

Jul 10, 2010·OncoTargets and Therapy·Argirios Moustakas, Teri N Kreisl
Jan 7, 2018·The Journal of Experimental Medicine·Takahiro SekiYihai Cao
Dec 20, 2017·Scientific Reports·Sun-Jung ChoYoung Ho Koh
May 24, 2018·FEBS Letters·Matthew KreitmanYosef Yarden
Jul 14, 2011·Journal of Cellular Physiology·Radhika SusarlaMargaret C Eggo
Jan 6, 2021·Journal of Nanobiotechnology·Hamed NosratiZohreh Alizadeh

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