PMID: 8958896Nov 1, 1996Paper

Gamma/delta cells in tissue from patients with sarcoidosis

Thorax
M L WilsherN M Birchall

Abstract

Because gamma/delta T lymphocytes (gamma delta cells) respond to myco-bacterial antigens in vitro and accumulate in the skin lesions of patients with certain granulomatous infections (leprosy, leishmaniasis), it was hypothesised that these cells might have a role in the pathogenesis of sarcoidosis, a disease also characterised by granuloma formation. Having failed to demonstrate an increase in gamma delta cells in the blood of patients with sarcoidosis, the aim of this study was to examine samples of bronchoalveolar lavage (BAL) fluid and biopsy tissue. Samples from 23 patients (13 women) with newly diagnosed sarcoidosis, of mean age 31 years and median percentage of lymphocytes in the BAL fluid of 31%, were studied. Controls included normal subjects and patients with other interstitial lung diseases (ILD). Cytopreparations of BAL fluid (n = 13) and cryostat sections (five mediastinal nodes, 14 transbronchial biopsies) were stained with alkaline phosphatase-antialkaline phosphatase and monoclonal antibodies to CD3, CD4, CD8, CD25, and gamma delta T cell receptor (TCR). All patients had typical chest radiographs (16 stage I, four stage II, three stage III). All were Mantoux negative with negative tuberculosis cultures. Compared ...Continue Reading

References

Feb 1, 1990·Immunology Today·W BornR O'Brien
Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·J GrunewaldA G Eklund
Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·K NakataM Aoki
Jan 1, 1993·The Journal of Clinical Investigation·J M ForresterB L Kotzin

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Citations

Dec 12, 2001·Survey of Ophthalmology·S R BoydS Lightman
Jun 15, 2007·Clinics in Dermatology·Aliya Noor, Kenneth S Knox

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