gammadelta T cells in cancer immunotherapy: current status and future prospects

Immunotherapy
Shubhada ChiplunkarDieter Kabelitz

Abstract

gammadelta T lymphocytes are a distinct T-cell subset that display unique features with respect to T-cell receptor (TCR) gene usage, tissue tropism and antigen recognition. Phosphoantigens contributed by a dysregulated mevalonate pathway or the bacterial nonmevalonate pathway and aminobisphosphonates are capable of activating Vgamma9Vdelta2 T cells. With the aid of synthetic phosphoantigens, large-scale expansion of gammadelta T cells and their adoptive transfer into human hosts is now possible. The present review summarizes triumphs and tribulations of clinical trials using gammadelta T-cell immunotherapy. Adoptive transfer of phosphoantigen-activated gammadelta T cells or coadministration with aminobisphosphonates/cytokines/monoclonal antibodies appear to be promising approaches for cancer immunotherapy. It can be predicted that a comprehensive understanding of the molecular interactions of this unique T-cell subset with other key immune regulators (dendritic cells and regulatory T cells) will provide an impetus to bring this modality of treatment from bench to bedside.

References

Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y TanakaC T Morita
Apr 1, 1996·The Journal of Experimental Medicine·M J MaeurerM T Lotze
Oct 1, 1996·European Journal of Immunology·Y PoquetJ J Fournié
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·A D LaadS V Chiplunkar
Mar 6, 1999·The New England Journal of Medicine·V KunzmannM Wilhelm
Oct 21, 1999·Biochemical and Biophysical Research Communications·E van BeekS Papapoulos
Mar 23, 2000·The Journal of Experimental Medicine·F M SpadaM B Brenner
Jan 3, 2001·Nature Medicine·X C LiT B Strom
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·B J ZhengM H Ng
Jul 24, 2001·European Journal of Immunology·G SireciA Salerno
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y KatoN Minato
Oct 25, 2001·The Journal of Biological Chemistry·Juliane FeurleMartin Wilhelm
Feb 28, 2002·Annual Review of Immunology·Lars E TheillJosef M Penninger
Dec 10, 2002·Cellular Immunology·Matthias EberlHassan Jomaa
Dec 18, 2002·The Journal of Experimental Medicine·David S LeslieMichael B Brenner
Jan 23, 2003·The Journal of Experimental Medicine·Hans-Jürgen GoberGennaro De Libero
Feb 7, 2003·Current Medicinal Chemistry·Philippe ClézardinOlivier Peyruchaud
Mar 11, 2004·Immunology·Brigitta StockingerGeorge Kassiotis
Mar 20, 2004·Critical Reviews in Immunology·Dieter Kabelitz, Daniela Wesch
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yvette E LatchmanArlene H Sharpe
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Maria Raffaella Zocchi, Alessandro Poggi
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Julie M JamesonWendy L Havran
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dieter KabelitzMargot Zöller
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucia ContiSandra Gessani
Feb 8, 2005·Biochemical and Biophysical Research Communications·Jack F BukowskiHiranmoy Das
Mar 10, 2005·International Journal of Cancer. Journal International Du Cancer·Kiyoshi SatoTaira Maekawa
Jun 4, 2005·Science·Marlène BrandesBernhard Moser

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Citations

Mar 8, 2016·Advances in Hematology·Mohammad Faizan Zahid, David Alan Rizzieri
Feb 6, 2014·Oncoimmunology·Alessandro Poggi, Maria Raffaella Zocchi
Jan 8, 2015·Frontiers in Immunology·Drew C DenigerLaurence J N Cooper
Apr 8, 2016·World Journal of Gastroenterology : WJG·Liang RongXiao-Yan Liu
Nov 3, 2010·Cellular & Molecular Immunology·Jianlei HaoZhinan Yin

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Methods Mentioned

BETA
transfection
GTPase
GTPases
xenograft
transgenic

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