PMID: 11923557Mar 30, 2002Paper

gammadelta T lymphocytes in the peripheral blood of patients with tuberculosis with and without HIV co-infection

Thorax
A C C CarvalhoG Carosi

Abstract

Several recent studies suggest that gammadelta T lymphocytes play an important role in immunity against Mycobacterium tuberculosis. However, the dynamics of these cells in the peripheral blood of patients with tuberculosis (TB) with and without HIV infection is not fully understood. A study was undertaken to evaluate the profile of the gammadelta T cell population in patients at the time the diagnosis of TB was established. A cross sectional study was performed in consecutive TB patients from the Department of Infectious Diseases, Spedali Civili, Brescia. CD4+, CD8+ and Vdelta1 and Vdelta2 T cell counts were analysed. Lymphocyte surface membrane expression was evaluated with the FITC-TCRgammadelta, -Vdelta1, -Vdelta2 and PE-Vdelta1 monoclonal antibodies. Blood donors and HIV seropositive asymptomatic individuals acted as controls. Seventy four TB patients were evaluated, 20 of whom (27%) were co-infected with HIV. HIV seronegative TB patients (n=54) had total gammadelta T cells and Vdelta1 subsets comparable to those in blood donors (n=39). However, the percentage with the Vdelta2 subset was significantly lower in patients with TB than in controls (median 1.5 v 2.1; p=0.05). Responsiveness to PPD was not associated with predomi...Continue Reading

References

Mar 1, 1992·The Journal of Infectious Diseases·P F BarnesR L Modlin
Oct 1, 1996·Research in Immunology·Y PoquetJ J Fournié
Dec 23, 1999·The Journal of Infectious Diseases·F DieliA Salerno

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Citations

Aug 3, 2006·Mediators of Inflammation·Figen DeveciFulya Ilhan
Jan 23, 2013·Arthritis Research & Therapy·Gunes ParlakgulGuher Saruhan-Direskeneli
Apr 13, 2010·Immunological Investigations·Jesús HernandezAdriana Garibay-Escobar
Feb 12, 2010·The Journal of International Medical Research·Y E WuY M Cai
Sep 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne BourgaritUNKNOWN PARADOX Study Group
May 22, 2003·Microbes and Infection·Zheng W Chen, Norman L Letvin

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