Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

PLoS Pathogens
Vickie A MarshallDenise Whitby

Abstract

Human gammaherpesviruses are associated with malignancies in HIV infected individuals; in macaques used in non-human primate models of HIV infection, gammaherpesvirus infections also occur. Limited data on prevalence and tumorigenicity of macaque gammaherpesviruses, mostly cross-sectional analyses of small series, are available. We comprehensively examine all three-rhesus macaque gammaherpesviruses -Rhesus rhadinovirus (RRV), Rhesus Lymphocryptovirus (RLCV) and Retroperitoneal Fibromatosis Herpesvirus (RFHV) in macaques experimentally infected with Simian Immunodeficiency Virus or Simian Human Immunodeficiency Virus (SIV/SHIV) in studies spanning 15 years at the AIDS and Cancer Virus Program of the Frederick National Laboratory for Cancer Research. We evaluated 18 animals with malignancies (16 lymphomas, one fibrosarcoma and one carcinoma) and 32 controls. We developed real time quantitative PCR assays for each gammaherpesvirus DNA viral load (VL) in malignant and non-tumor tissues; we also characterized the tumors using immunohistochemistry and in situ hybridization. Furthermore, we retrospectively quantified gammaherpesvirus DNA VL and SIV/SHIV RNA VL in longitudinally-collected PBMCs and plasma, respectively. One or more gam...Continue Reading

References

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Citations

Jul 3, 2019·International Journal of Cancer. Journal International Du Cancer·Nazzarena LaboDenise Whitby
Oct 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afam A OkoyeLouis J Picker
Jul 29, 2020·Viruses·Monika A ZelazowskaLaurie T Krug
Mar 4, 2021·PLoS Pathogens·Anna K GroßkopfAlexander S Hahn
Jun 16, 2021·ILAR Journal·Chandra SaravananHsi-Yu Yen

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Methods Mentioned

BETA
PCR
biopsies
biopsy
SMA
ELISAs
ELISA
dissecting
dissection

Software Mentioned

GeneRunner
Primer Express
LOWESS

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