PMID: 8588338Nov 1, 1995Paper

Gammopathy with two M-components in a dog with IgA-type multiple myeloma

Veterinary Immunology and Immunopathology
H KatoA Hasegawa

Abstract

A 12-year neutered male mixed-breed dog was referred to hospital for evaluation of chronic diarrhea. Cellulose acetate electrophoresis of its serum revealed two monoclonal peaks in the gamma-globulin fraction. On immunoelectrophoretic analysis, the two monoclonal peaks in the gamma-globulin region were strongly precipitated with anti-dog IgA serum. On sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis, the fractions corresponding to these two peaks were shown to be dimer and trimer or tetramer of immunoglobulin consisting of heavy and light chains. These results indicated that the studied dog had gammopathy with two M-components with dimer and trimer or tetramer of IgA. Accumulations of large amounts of these immunoglobulins with very high molecular weight in the serum were concluded to induce the hyperviscosity syndrome in this dog in the terminal stage.

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Citations

Aug 23, 2005·Journal of Feline Medicine and Surgery·Fikry Hanna
Oct 3, 1999·Veterinary Immunology and Immunopathology·N C Pedersen
Jun 1, 2002·Veterinary Clinical Pathology·Shashi K RamaiahR E Raskin
Dec 6, 2008·Veterinary Clinical Pathology·Silvia RossiAlessia Giordano
Aug 30, 2011·The Journal of Veterinary Medical Science·Shinya FukumotoTsuyoshi Uchide
Sep 10, 2003·Journal of the American Veterinary Medical Association·Sarah J LautzenhiserRobert L Goring
Mar 23, 2002·Journal of the American Animal Hospital Association·Jérĵme M GiraudelJean-François Guelfi
Dec 8, 2015·The Journal of Veterinary Medical Science·Masaya IgaseMasaru Okuda

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