Abstract
Surgical implantation of the intraocular sustained-release ganciclovir device is a safe and effective treatment for cytomegalovirus (CMV) retinitis. Previous histopathologic studies on eyes containing such implants have been limited by the necessity of removing the device before processing. Microtome sectioning of hard plastics within paraffin-embedded blocks is infeasible, and the anatomic relations of implant to eye are destroyed. The authors studied four eyes from three patients who had undergone implant insertion. Globes with implants in place were fixed in neutral 10% formation, embedded in methylmethacrylate, sectioned on a special microtome, and stained with hematoxylin-eosin. After methacrylate embedding, the precise anatomic relations of the implant to the neighboring uveoscleral coats were preserved. In two eyes, the suture tab of the implant protruded through the sclera, exiting subconjunctivally. In two eyes, the implant was totally intravitreal. In all patients, the device was supported by fibrous tissue which emanated from a surgical coloboma of the pars plana ciliaris. Focal granulomatous inflammation adjoined suture and implant materials but no other inflammation or deleterious effects on the ocular structures w...Continue Reading
References
Feb 1, 1992·Archives of Ophthalmology·T J SmithP Ashton
Sep 1, 1991·Ophthalmology·I Cochereau-MassinW Rozenbaum
Nov 1, 1986·Kidney International·M C Faugere, H H Malluche
Dec 1, 1989·Archives of Ophthalmology·M H Heinemann
Jul 1, 1987·Ophthalmology·D A JabsB F Polk
Apr 1, 1995·American Journal of Ophthalmology·L S KirschW R Freeman
Jul 1, 1993·Ophthalmology·R AnandS D Nightingale
Citations
Dec 12, 2001·Survey of Ophthalmology·I M Siegel
Aug 26, 1998·Antiviral Research·J W Cohen StuartR J Whitley
Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M MerodioJ M Irache
Mar 22, 2002·Acta Ophthalmologica Scandinavica·Fredrik GhoshAlbert N Békássy
Apr 12, 2001·Contact Dermatitis·M R Holdiness
Feb 7, 2001·Eye·N H al-YousufJ Ironside
Apr 13, 2004·Retina·James P DunnUNKNOWN Studies of Ocular Complications of AIDS Research Group
Jan 29, 2002·American Journal of Ophthalmology·Norman C Charles, Lars Freisberg
Jul 26, 2002·The British Journal of Ophthalmology·S KunimatsuM Araie
Dec 25, 2010·Veterinary Ophthalmology·Alan L Weiner, Brian C Gilger
Nov 17, 2006·Advanced Drug Delivery Reviews·J L BourgesF Behar-Cohen
May 3, 2006·Ophthalmology·Norman C Charles
May 10, 2005·Ophthalmology·Sunil K SrivastavaChi-Chao Chan
Feb 16, 2008·Drug Discovery Today·Sanjeeb K SahooS Krishnakumar
May 1, 1997·American Journal of Ophthalmology·P F McAuliffeM H Heinemann
Jul 22, 2005·Clinical & Experimental Ophthalmology·Monte Kahn
Apr 7, 2020·Lab on a Chip·Nicola Di TraniAlessandro Grattoni
Oct 27, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Usha Ganganahalli KapanigowdaPrakash Rao Boggarapu
Jul 28, 2020·Pharmaceutics·Nicola Di TraniAlessandro Grattoni
Feb 13, 2008·Journal français d'ophtalmologie·J-L BourgesF Behar-Cohen