PMID: 7542425Jan 1, 1995Paper

Ganglioglioma with neurofibrillary tangles (NFTs): neoplastic NFTs share antigenic determinants with NFTs of Alzheimer's disease

Acta Neuropathologica
D SofferJ E Goldman

Abstract

A cerebral ganglioglioma contained abundant neurofibrillary tangles (NFTs) of the paired helical filament (PHF) type. The NFTs in the tumor were argyrophilic and Congo red and thioflavin-S positive. Immunohistochemically, the NFTs were reactive with antibodies to phosphorylated neurofilament protein, PHF/tau and ubiquitin. The demonstration in the neoplasm of abnormally phosphorylated and ubiquitinated cytoskeletal components, similar in morphology and in immunoreactivity to those seen in NFTs of Alzheimer's disease, suggest that similar pathogenetic mechanisms may operate in both conditions.

References

Mar 1, 1979·Annals of Neurology·K WisniewskiH M Wisniewski
Nov 10, 1992·Biochimica Et Biophysica Acta·J P Brion
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G WoodL I Binder
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G PerryV Chau
Sep 1, 1984·Human Pathology·M A Oberc-GreenwoodB H Smith
Dec 1, 1993·Journal of Neurosurgery·D C MillerF J Epstein
Jan 1, 1993·Brain Pathology·K S Kosik
Jan 1, 1993·Brain Pathology·J LoweM Landon

❮ Previous
Next ❯

Citations

Feb 2, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Seiji YamadaHideaki Yokoo
Aug 15, 2017·The International Journal of Neuroscience·Katarzyna Drapalo, Jaroslaw Jozwiak
Apr 20, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Seiji YamadaMark E Jentoft
Dec 15, 2018·Neuroscience and Biobehavioral Reviews·Marija Rankovic, Markus Zweckstetter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.