Ganglion-blocking agents enhance neurally mediated bronchoconstriction in the guinea-pig: possible role of sensory neuropeptides

European Journal of Pharmacology
M Del MonteA Subissi


The effect of ganglion blockade by hexamethonium bromide (0.1-100 and pentolinium tartrate (0.01-3 on the bronchoconstriction induced by vagal nerve stimulation (15 Hz, 0.2 ms, 3 s, 7-20 V) was evaluated in the anaesthetized guinea-pig. Both ganglion-blocking agents potentiated this response dose dependently. When the neural bronchoconstriction was suppressed by atropine, hexamethonium restored this response dose dependently. Hexamethonium produced inhibitory effects on vagally induced bronchoconstriction in capsaicin-desensitized and in propranolol- or reserpine-pretreated guinea-pigs. Propranolol (0.03-3 produced a marked dose-dependent increase of neural bronchoconstriction (which was markedly reduced, about 10 times) in capsaicin-desensitized animals. Our results show that ganglion-blocking agents potentiate neural bronchoconstriction in the guinea-pig and that sensory neuropeptides may have a role in this effect. Moreover, beta-adrenergic modulation of the release of neuropeptides from vagal sensory fibers is suggested.


Oct 1, 1988·British Journal of Pharmacology·M G BelvisiP J Barnes
Dec 1, 1967·European Journal of Pharmacology·M W McCullochM J Rand
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers
Feb 1, 1983·British Journal of Pharmacology·C AdvenierA Renier
Dec 1, 1984·British Journal of Pharmacology·A D Fryer, J Maclagan

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