PMID: 19108132Mar 1, 1960

Ganglion-blocking properties of atropine-like drugs

British Journal of Pharmacology and Chemotherapy
J G BAINBRIDGE, D M BROWN

Abstract

The ganglion-blocking properties of atropine, atropine methyl nitrate, oxyphenonium, poldine, methantheline and propantheline have been examined and compared with those of hexamethonium, mecamylamine, pentolinium and tetraethylammonium. The ganglion-blocking activity was assessed by stimulating the preganglionic nerve to the superior cervical ganglion and recording directly the percentage depression in the postganglionic action potentials. In this way any ambiguity due to the peripheral actions of the drugs was removed. As a group the atropine-like compounds are not markedly less potent than the ganglion-blocking agents, but their action is relatively transient. This work suggests that the ganglion-blocking action of atropine-like substances plays no part in their therapeutic effects.

Citations

Apr 25, 2012·European Journal of Clinical Pharmacology·Christian MüllerWerner Siegmund
May 23, 1994·European Journal of Pharmacology·B I Gustafsson, D S Delbro
Jan 1, 1979·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·P YavariG A Kerkut
Oct 1, 1963·British Journal of Pharmacology and Chemotherapy·S D GOKHALEN Y JOSHI
Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·J P QUILLIAM, D G SHAND
Sep 1, 1970·British Journal of Pharmacology·P J Watson
Sep 1, 1966·The Journal of Pharmacy and Pharmacology·R M Quinton

Related Concepts

Atropine
Autonomic Fibers, Postganglionic
Mental Depression
Mecamylamine
Methantheline
Oxyphenonium
Pentolinium
Propantheline
Hexamethonium
Poldine

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