PMID: 7546696May 1, 1995Paper

Ganglion cell death in glaucoma: pathology recapitulates ontogeny

Australian and New Zealand Journal of Ophthalmology
Harry A Quigley

Abstract

I review some improvements in our knowledge about the death of retinal ganglion cells in glaucoma during the last 20 years. These include the realisation that glaucoma damage precedes its detection by perimetry, the fact that the lamina cribrosa is a major site of axonal injury to ganglion cells, and the association between regional structure of optic nerve head connective tissue and the pattern of glaucoma damage. The selective susceptibility of larger retinal ganglion cells and its functional significance are described. Apoptosis is the mode of cell death in at least some ganglion cells in experimental glaucoma. This supports a theory that retrograde axonal transport failure leads to loss of trophic factor influence on ganglion cells, causing them to initiate their own suicide. As a consequence of this theory, two therapeutic avenues are suggested for prevention of glaucoma injury and cell death: delivery of trophic factors and manipulation of ganglion cell genetic expression of controlling influences over programmed cell death.

References

Nov 15, 1992·American Journal of Ophthalmology·R VarmaM E Pease
Apr 1, 1992·Archives of Ophthalmology·Y GlovinskyH D Jampel
Sep 1, 1991·The British Journal of Ophthalmology·H A QuigleyM E Dorman-Pease
Jul 1, 1990·Archives of Ophthalmology·J C MorrisonH A Quigley
May 15, 1989·American Journal of Ophthalmology·H A QuigleyW R Green
Jan 1, 1973·Neurologia Medico-chirurgica·W F Hoyt
Apr 1, 1981·Archives of Ophthalmology·H A QuigleyA E Maumenee
Nov 1, 1984·Archives of Ophthalmology·R L Radius, J E Pederson
May 1, 1983·American Journal of Ophthalmology·H A QuigleyW R Green
May 1, 1982·Archives of Ophthalmology·H A Quigley, E M Addicks
Mar 1, 1981·Archives of Ophthalmology·R L Radius
Jul 15, 1994·American Journal of Ophthalmology·R N WeinrebP Sample
Apr 1, 1994·Journal of Neurobiology·E Garcia-ValenzuelaS C Sharma
Aug 15, 1993·American Journal of Ophthalmology·N ChaturvediE B Dreyer
May 1, 1993·Archives of Ophthalmology·C A JohnsonJ D Brandt

❮ Previous
Next ❯

Citations

Oct 19, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N N Osborne, K-G Schmidt
Feb 2, 2013·Cell and Tissue Research·Eduardo M NormandoM Francesca Cordeiro
Aug 13, 2010·Journal of Molecular Neuroscience : MN·Kimi EndoSeiji Shioda
Dec 19, 2003·Micron : the International Research and Review Journal for Microscopy·Nadia Campos de Oliveira MiguelSilvana Allodi
Jan 27, 1999·Progress in Retinal and Eye Research·H A Quigley
Nov 26, 2009·Visual Neuroscience·Iona D RaymondNicholas C Brecha
Dec 13, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Eric J SiglerNils A Loewen
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·J C Vickers
Dec 11, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ian F Gutteridge
Jul 22, 1999·The British Journal of Ophthalmology·N N OsborneM S Nash
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Richard T LibbySimon W M John
Jun 3, 2008·Canadian Journal of Physiology and Pharmacology·Raghu R KrishnamoorthyThomas Yorio
Dec 27, 2005·FEBS Letters·Dmitry IvanovValery I Shestopalov
Oct 26, 2005·The Journal of Cell Biology·Tatjana C JakobsRichard H Masland
Jul 2, 2005·Expert Opinion on Emerging Drugs·Abbot F Clark, Iok-Hou Pang
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ji-Jie PangSamuel M Wu
Aug 6, 2010·Experimental Eye Research·Thomas V JohnsonKeith R Martin
Feb 17, 2009·Experimental Eye Research·Elaine C JohnsonJohn C Morrison
Oct 17, 2015·Experimental Eye Research·Jia-Ying ChienShun-Ping Huang
Aug 15, 2008·Clinical & Experimental Ophthalmology·Michael S SchoberRobert J Casson
Nov 26, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Vickie H Y WongAlgis J Vingrys
Dec 22, 2004·Progress in Retinal and Eye Research·John C MorrisonLijun Jia
Apr 29, 2006·Biochemical and Biophysical Research Communications·Saiyuu YuNagahisa Yoshimura
Feb 18, 2014·Ophthalmic Epidemiology·Janice S H LamTien Yin Wong
May 4, 2002·Molecular and Cellular Neurosciences·Gail M SeigelHannah M Mitchison
Aug 17, 2014·Experimental Eye Research·Jan Darius UnterlauftWolfram Eichler
Oct 22, 2008·Progress in Brain Research·S C Sharma
Aug 7, 2007·The British Journal of Nutrition·Francesca L CroweAndrew R Gray
Jan 10, 2002·Journal of Neuroscience Research·Pawel Grieb, Robert Rejdak
May 8, 2000·Journal of Neuroscience Research·A AgarM T Coroneo
Sep 12, 2000·Clinical & Experimental Ophthalmology·P N DimitrovC A McCarty
Jan 28, 2014·Current Opinion in Ophthalmology·O'Rese J Knight, Scott D Lawrence

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis