Ganglioside GD3 and GD3-lactone mediated regulation of the intermolecular organization in mixed monolayers with dipalmitoylphosphatidylcholine

Chemistry and Physics of Lipids
Bruno MaggioR K Yu

Abstract

The interactions of dpPC with ganglioside GD3 and two lactones. GD3LacI or GD3LacII, in lipid monolayers occur with reduced, unaltered, or increased molecular area and surface potential/molecule, respectively. dpPC is fully miscible with GD3 and GD3LacI but films with GD3LacII show immiscibility above 75 mol% lactone. At low proportions of GD3 in mixtures with dpPC, GD3 undergoes condensation and depolarization; dpPC is depolarized and its molecular area is reduced above 50 mol% GD3. GD3LacI forms ideally mixed films with dpPC. Mixtures of dpPC with GD3LacII at mole fractions below 0.3 show increased mean molecular area and surface potential/molecule mostly due to lactone alterations. Between mole fractions of 0.3 and 0.75 the surface parameters of dpPC are altered, and above these proportions both lipids are immiscible. Defined variations of molecular properties induced by ganglioside lactonization are selectively transduced to changes of the intermolecular organization and surface electrostatics in mixed interfaces with dpPC. Thus, changes in the relative proportions of a ganglioside and its lactone forms may act as sensitive biotransducers for membrane-mediated cellular functions, without the need for metabolically altering ...Continue Reading

References

May 1, 1976·The Biochemical Journal·B Maggio, J A Lucy
Sep 1, 1975·The Biochemical Journal·B Maggio, J A Lucy
Aug 15, 1985·Archives of Biochemistry and Biophysics·B MaggioR K Yu
Jan 1, 1994·Progress in Biophysics and Molecular Biology·B Maggio

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Citations

Jan 6, 2009·The Journal of Membrane Biology·Monika Naumowicz, Zbigniew Artur Figaszewski
Dec 10, 2008·Biochimica Et Biophysica Acta·Laura Cantu'Elena Del Favero
Mar 31, 2005·Journal of Colloid and Interface Science·Augusto BellomioRoberto D Morero
Jan 27, 2005·Biochimica Et Biophysica Acta·Graciela A BorioliBruno Maggio
Dec 26, 2003·Biophysical Journal·Marco DiociaiutiPietro Chistolini
May 26, 2005·Journal of Colloid and Interface Science·Maximiliano Del BocaGraciela A Borioli
Oct 30, 2009·Physical Chemistry Chemical Physics : PCCP·Melanie RöefzaadIzabella Brand
Aug 22, 2017·Biophysics Reviews·María Laura Fanani, Bruno Maggio
Jan 7, 2020·Current Medicinal Chemistry·Konstantin Andreev
Oct 27, 2018·Chemical Reviews·Marek CebecauerMartin Hof

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