Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer.

Journal of Oncology
Thomas N Seyfried, Purna Mukherjee

Abstract

Progression of malignant brain tumors is dependent upon vascularity and is associated with altered ganglioside composition and distribution. Evidence is reviewed showing that the simple monosialoganglioside, GM3, possesses powerful antiangiogenic action against the highly vascularized CT-2A mouse astrocytoma, which primarily expresses complex gangliosides. Brain tumors expressing high levels of GM3 are generally less vascularized and grow slower than tumors that express low levels of GM3. GM3 inhibits angiogenesis through autocrine and paracrine effects on vascular endothelial growth factor (VEGF) and associated receptors. GM3 should be a clinically useful compound for managing brain tumor angiogenesis.

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Citations

Jul 24, 2013·Analytical and Bioanalytical Chemistry·Alina D ZamfirCorina Flangea
Oct 30, 2013·Angiogenesis·Yihui LiuStephan Ladisch
Jan 1, 2013·Cells·Sylvain JulienPhilippe Delannoy
Aug 3, 2013·Biochimica Et Biophysica Acta·Michał FlasińskiPatrycja Dynarowicz-Łątka
May 24, 2018·Organic & Biomolecular Chemistry·Hai YuXi Chen
Oct 6, 2017·The Journal of Pathology·Nicholas Jc SmithTimothy M Cox
May 7, 2019·Current Medicinal Chemistry·Daniele BottaiRiccardo Ghidoni

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