Ganglioside potentiation of NGF-independent conditioned medium enhancement of neuritic outgrowth from spinal cord and ciliary ganglia explants

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
P E Spoerri, F J Roisen

Abstract

Culture medium conditioned (CM) by embryonic chick skeletal muscle or RN22 Schwannoma cells enhanced dramatically the neuritic development of chick embryonic spinal cord slices explanted onto a collagen substratum. The addition of a mixture of bovine brain gangliosides (BBG) or the monosialoganglioside GM1 to this medium potentiated the nerve growth factor (NGF)-independent CM-mediated neuritogenesis. A 3-4 fold increase in spinal cord outgrowth was due to increased neurite number, length and branching. The ability of the gangliosides to potentiate the positive neuritogenic action of CM was not limited solely to spinal cord cultures since similar results were obtained in parallel studies employing organized cultures of embryonic chick ciliary ganglia. These studies demonstrate the ability of gangliosides to enhance the trophic action of factor(s) present in CM. They suggest further that gangliosides may play a modulatory role in the development of the nervous system.

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Citations

Nov 1, 1990·Brain Research. Developmental Brain Research·P E SpoerriF J Roisen
Jul 17, 1989·Neuroscience Letters·H Laev, S P Mahadik
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P E SpoerriF J Roisen
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D W SingletonF J Roisen
Oct 1, 1992·Journal of Autonomic Pharmacology·P S Lorenzo, E Adler-Graschinsky

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