Gangliosides and phospholipids in human thyroids responsive and unresponsive to thyrotropin

Journal of Endocrinological Investigation
A MarianoV Macchia

Abstract

The patterns of gangliosides and phospholipids and their relation to TSH response were examined in twenty-six malignant thyroid tumors (4 follicular, 6 papillary, 5 medullary, 11 anaplastic carcinomas) and thirty-six hyperplastic goiters. Thirteen thyroid tissues adjacent to benign tumors with no evidence of macroscopic or microscopic abnormalities were used as normal tissue. In normal thyroids the major ganglioside was GD3 (44%) and GM3 was the second ganglioside (20%). In minor amounts GD1a (8.6%), GD1b (6.2%), GT1b (5.7%) and GM1 (5.6%) were present. In hyperplastic goiters and in follicular carcinomas the patterns of gangliosides were similar to that of normal tissue except for GM3 which, in the last tissue, was higher (34%). In papillary carcinomas low levels of GM3 (11%) and GT1b (0.8%) with a high level of GD1b (12.6%) were found. In anaplastic carcinomas GM3 was very high (47%) whereas GD3 was low (18%). In these tumors also a high percentage (14.0%) of GD1a was found. In medullary carcinomas the lowest levels of GM3 (4%) with the highest level of GD3 (64%) were found. Although large differences of the gangliosides distribution were clearly encountered in the various pathological human thyroid, no correlation between la...Continue Reading

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Citations

Feb 1, 1993·Journal of Endocrinological Investigation·A Di CarloV Macchia
Dec 1, 1993·The Journal of Urology·D S HoonR F Irie
May 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Helen C CocksMargaret C Eggo
Apr 9, 2005·International Journal of Cancer. Journal International Du Cancer·Mepur H RavindranathDonald L Morton
Dec 26, 2001·Immunology Letters·Aleksandra LewartowskaWanda Wojciechowska
Apr 6, 2004·Molecular and Cellular Endocrinology·Margaret C EggoSpencer Campbell
Jul 3, 2021·International Journal of Molecular Sciences·Karin SäljöSusann Teneberg

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