Dec 1, 1994

Gangliosides as diagnostic markers of human astrocytomas and primitive neuroectodermal tumors

Cancer
C C SungA J Yates

Abstract

Limitations of classification schemes for brain tumors based solely on morphology have stimulated searches for molecular markers of nosologic and prognostic value. Gangliosides are logical candidates because there are high concentrations of them in the nervous system, there is evidence of their roles in regulation of growth and differentiation, and data from small series suggest correlations between ganglioside composition and glioma type. Ganglioside compositions were determined for 70 primary human brain tumors: 16 low grade astrocytomas (LG), 12 anaplastic astrocytomas (AA), 34 glioblastoma multiformes (GBM), and 8 primitive neuroectodermal tumors (PNET). This method involved identification and quantitation of specific gangliosides using chemical analysis and immunoanalysis. Among all tumor types, histologic grade correlated with a progressive loss of 1b gangliosides (P < 0.0001). GQ1b was higher in LGs than in AAs (P < 0.001). Both GT1b and GD1b were higher in AAs than GBMs (P < 0.01 and 0.05, respectively) and lower in PNETs than in GBMs (P < 0.05). GM3 was higher in PNETs than in any astrocytoma group and higher in GBMs than in either AAs or LGs. There was a significant difference in the content of 3'-LM1 among all groups...Continue Reading

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References

Mentioned in this Paper

Glioblastoma Multiforme
Mixed Oligoastrocytoma
Anaplastic Astrocytoma
Science of Morphology
Entire Nervous System
Regulation of Growth
Extraosseous Ewings Sarcoma-primitive Neuroepithelial Tumor
Ganglioside, GD3
Neuroectodermal Tumor, Primitive
Tumor Markers

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