Gangliosides in Inflammation and Neurodegeneration

Progress in Molecular Biology and Translational Science
Koichi FurukawaKeiko Furukawa

Abstract

Gangliosides play roles in the regulation of cell signaling that are mediated via membrane microdomains, lipid rafts. In this review, functions of gangliosides in the maintenance of nervous systems with a focus on regulation of inflammation and neurodegeneration are addressed. During analyses of various ganglioside-lacking mutant mice, we demonstrated that nervous tissues exhibited inflammatory reactions and subsequent neurodegeneration. Among inflammation-related genes, factors of the complement system showed up-regulation with aging. Analyses of architectures and compositions of lipid rafts in nervous tissues from these mutant mice revealed that dysfunctions of complement regulatory proteins based on disrupted lipid rafts were main factors to induce the inflammatory reactions resulting in neurodegeneration. Ganglioside changes in development and senescence, and implication of them in the integrity of cell membranes and cellular phenotypes in physiological and pathological conditions including Alzheimer disease have been summarized. Novel directions to further analyze mechanisms for ganglioside functions in membrane microdomains have been also addressed.

Citations

Mar 12, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Koichi FurukawaKeiko Furukawa
Jul 25, 2019·Organic & Biomolecular Chemistry·Ingrid M E 't HartGeert-Jan Boons
Jul 31, 2019·Biomolecules·Sumeyye CavdarliPhilippe Delannoy
Jan 12, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yu WangYanzhi Song
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Kei HanafusaKazuhisa Iwabuchi
Feb 15, 2021·European Journal of Medicinal Chemistry·Yang LiuLixia Chen

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