Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress.

Glycobiology
Richard JennemannHermann-Josef Gröne

Abstract

In pancreatic beta cells, the entry of glucose and downstream signaling for insulin release is regulated by the glucose transporter 2 (Glut2) in rodents. Dysfunction of the insulin-signaling cascade may lead to diabetes mellitus. Gangliosides, sialic acid-containing glycosphingolipids (GSLs), have been reported to modulate the function of several membrane proteins.Murine islets express predominantly sialylated GSLs, particularly the simple gangliosides GM3 and GD3 having a potential modulatory role in Glut2 activity. Conditional, tamoxifen-inducible gene targeting in pancreatic islets has now shown that mice lacking the glucosylceramide synthase (Ugcg), which represents the rate-limiting enzyme in GSL biosynthesis, displayed impaired glucose uptake and showed reduced insulin secretion. Consequently, mice with pancreatic GSL deficiency had higher blood glucose levels than respective controls after intraperitoneal glucose application. High-fat diet feeding enhanced this effect. GSL-deficient islets did not show apoptosis or ER stress and displayed a normal ultrastructure. Their insulin content, size and number were similar as in control islets. Isolated beta cells from GM3 synthase null mice unable to synthesize GM3 and GD3 also ...Continue Reading

References

Nov 1, 1991·Glycobiology·R L Schnaar
Nov 1, 1989·Diabetes·F DottaR C Nayak
Mar 19, 1993·Science·L M ObeidY A Hannun
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·N Bégin-Heick
Jan 27, 1999·Biochemical and Biophysical Research Communications·S IchikawaY Hirabayashi
Apr 25, 2000·Archives of Biochemistry and Biophysics·M Saito, K Sugiyama
May 1, 2001·Methods : a Companion to Methods in Enzymology·D Metzger, P Chambon
Nov 15, 2001·The Journal of Biological Chemistry·Seiichi TagamiYasuyuki Igarashi
Jan 22, 2002·The Journal of Cardiovascular Nursing·Barbara FletcherCindy Lamendola
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tadashi YamashitaRichard L Proia
Jul 30, 2004·Genesis : the Journal of Genetics and Development·Fatima el MarjouSylvie Robine
Aug 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Richard JennemannHermann-Josef Gröne
Sep 7, 2005·Diabetologia·K BuschardP Fredman
Dec 6, 2005·The Journal of Biological Chemistry·Ji-Yeon LeeLothar Hennighausen
Feb 9, 2007·Diabetes·Johannes M AertsHermen S Overkleeft
Mar 6, 2007·The Journal of Biological Chemistry·Laura PickersgillStephen J Yeaman
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kazuya KabayamaJin-ichi Inokuchi
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Jakob Suckale, Michele Solimena
Oct 31, 2009·Nature Protocols·Dong-Sheng LiLong-Jun Dai
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
May 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard JennemannHermann-Josef Gröne
May 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ünal CoskunKai Simons
Nov 1, 2011·Human Molecular Genetics·Richard JennemannRoger Sandhoff
Aug 2, 2012·The Journal of Biological Chemistry·Richard JennemannHermann-Josef Gröne
Apr 4, 2013·Biochemical and Biophysical Research Communications·Kazuaki OhtsuboNaoyuki Taniguchi
Nov 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jing Wang, Robert K Yu
Dec 1, 2008·Obesity Research & Clinical Practice·Takashige SatoJin-Ichi Inokuchi
Jan 1, 2012·ISRN Biochemistry·Thomas Kolter
Jun 16, 2016·The Journal of Biological Chemistry·Richard C HreskoPaul W Hruz
Oct 19, 2016·International Journal of Molecular Sciences·Domenico RussoGiovanni D'Angelo
Aug 3, 2017·Journal of Molecular Endocrinology·Dennis BrüningIngo Rustenbeck
Jan 10, 2018·Oncotarget·Richard JennemannHermann-Josef Gröne
Apr 20, 2018·Diabetologia·Laurits J HolmKarsten Buschard

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis