Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells

Life Sciences
Ue-Min ChangShwu-Bin Lin

Abstract

Ganoderiol F (GolF), a tetracyclic triterpene, was isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines. GolF induced growth arrest of cancer cell lines HepG2, Huh7 and K562, but exerted much less effect in hepatoma Hep3B cells and normal lung fibroblast MRC5 cells, and no effect on peripheral blood mononuclear cells. GolF treatment of the cancer cells, with the exception of Hep3B, resulted in prompt inhibition of DNA synthesis and arrest of cell progression cycle in G1 phase. Short-term exposure of HepG2 cells to GolF temporarily arrested progression of the cell cycle; cell growth was recovered if the drug was withdrawn from the medium after a 24-h exposure. After 18 days of continuous treatment of HepG2 cells with 30 muM GolF, over 50% of cells were found to be enlarged and flattened, and were beta-galactosidase positive phenotypes of senescent cells. GolF was found to inhibit activity of topoisomerases in vitro, which may contribute to the inhibition of cellular DNA synthesis. Activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of GolF treatment and were presumed to cause cell-cycle arrest and trigger pr...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jan 1, 1996·Annual Review of Biochemistry·J C Wang
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·D A AlcortaJ C Barrett
Sep 28, 1998·Biochimica Et Biophysica Acta·D A Burden, N Osheroff
Dec 23, 1998·Phytochemistry·S el-MekkawyT Otake
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C GoodwinE S Hwang
Feb 9, 2002·Nature Cell Biology·Alison C Lloyd
Mar 21, 2002·Nature Reviews. Cancer·N F Mathon, A C Lloyd
Aug 6, 2003·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Ming-Shi Shiao
Apr 13, 2004·Oncogene·Jerry W Shay, Igor B Roninson
May 13, 2004·Biogerontology·Koji ItahanaGoberdhan P Dimri
Aug 6, 2005·Science·Judith Campisi

❮ Previous
Next ❯

Citations

Oct 25, 2012·Journal of Natural Products·José-Luis RíosRosa-María Giner
Sep 26, 2009·Natural Product Reports·Reen-Yen KuoKuo-Hsiung Lee
Dec 24, 2011·Assay and Drug Development Technologies·Timo WeilandSascha Venturelli
Oct 5, 2011·World Journal of Hepatology·Roslin J Thoppil, Anupam Bishayee
Sep 11, 2014·Journal of Cancer Research and Therapeutics·Weisan ZhangPing Lei
Feb 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bing HuLing Xu
Dec 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ela Alcántara-FloresMariano Martínez-Vázquez
Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Balraj Singh GillSanjeev Kumar
Aug 17, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Uday BhanuAnand Kumar Kondapi
Aug 5, 2009·International Immunopharmacology·Shailesh DudhgaonkarDaniel Sliva
Jun 27, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cheng-chin HsuMei-chin Yin
Jan 26, 2012·Phytotherapy Research : PTR·Hui LuLiang Feng
May 14, 2014·The Journal of Pharmacy and Pharmacology·Natasha BeukesCarminita L Frost
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chien-Huang LiaoJiunn-Liang Ko
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Balraj Singh GillSanjeev Kumar
May 15, 2007·Canadian Journal of Microbiology·Wenbin LiuChengchao Shou
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramandeep KaurDinesh Kumar
Aug 22, 2015·Phytotherapy Research : PTR·Weimei RuanDavid G Popovich
Oct 8, 2019·3 Biotech·Adhiraj Dasgupta, Krishnendu Acharya
Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingxin MaKai Zheng
Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zaira Tavarez-SantamaríaMariano Martínez-Vázquez
Oct 23, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Tao WangJun Chen
Jan 13, 2017·Journal of Natural Medicines·Toshitaka KohnoKuniyoshi Shimizu
Jul 8, 2017·Current Medicinal Chemistry·Manee Patanapongpibul, Qiao-Hong Chen
Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nurhisyam ZakariaNoor Hasima Nagoor
Nov 13, 2020·Toxicology Research·Yuehui LiangFang Xiao
Nov 12, 2010·Journal of Agricultural and Food Chemistry·Cheng-Po HuangShwu-Bin Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.