Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associated with autophagy in immunosuppressed mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Mengxi YingMingyong Xie

Abstract

The aim of this study was to investigate the protective effect and underlying mechanisms of Ganoderma atrum polysaccharide (PSG-1) on cyclophosphamide (Cy)-induced intestinal mucosal dysfunction in mice. Results showed that PSG-1 promoted the formation of IgA-secreting cells, modulated sIgA, IgE, IgG, IgM secretion, and improved TLR-2, TLR-4, TLR-6 mRNA levels while these factors were suppressed after Cy treatment. CD4+ and CD8+ T cell numbers were also elevated by PSG-1. Cytokines including IFN-γ, TNF-α, IL-2, IL-12p70, IL-4, IL-1β, IL-17, IL-21, IL-23, TGF-β3 and transcription factors including T-bet, GATA-3, RORγt, Foxp3 increased after PSG-1 administration. Besides, PSG-1 reversed goblet cell numbers, and upregulated tight junction proteins like ZO-1, occludin and claudin-1 in immunosuppressed mice. Apart from these, the autophagy-related proteins LC3, Beclin-1, Atg5 and Atg7 were enhanced by PSG-1. These findings demonstrated that PSG-1 could ameliorate Cy-induced impairment of intestinal immunity and mucosal integrity, which maybe associated with autophagy in mice.

Citations

Sep 16, 2020·Protein & Cell·Tzu-Lung LinHsin-Chih Lai
Mar 11, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Wanyan LiNan Cao
May 29, 2021·International Journal of Biological Macromolecules·Yuxi GuoPin Gong
Jul 3, 2021·International Journal of Molecular Sciences·Thu Han Le PhanSeung Hyun Oh
Aug 10, 2021·Frontiers in Physiology·Karien Sauruk da SilvaDaniele Maria-Ferreira
Oct 30, 2021·Critical Reviews in Food Science and Nutrition·Bing ZhengQiang Yu

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