Ganoderma atrum polysaccharide attenuates oxidative stress induced by d-galactose in mouse brain

Life Sciences
Wenjuan LiMing He

Abstract

Ganoderma atrum polysaccharide (PSG-1), the main constituent of G. atrum, has been reported to attenuate oxidative stress in vitro. The aim of this study was to investigate whether PSG-1 has a protective effect on the brain against oxidative stress induced by D-galactose (D-gal) in vivo. Mice were intraperitoneally (i.p.) injected with D-gal (100 mg/kg body weight) once daily for 10 weeks. From the seventh week, D-gal-treated mice received PSG-1 (50, 100, or 150 mg/kg body weight) once daily for the last 4 weeks. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GSH-Rd), and the contents of glutathione (GSH), glutathione disulfide (GSSG) and malondialdehyde (MDA) in the brain were measured using different biochemical methods to evaluate the changes of the antioxidant ability in the PSG-1 treated mice. Apoptosis, reactive oxygen species (ROS) and calcium levels were determined by flow cytometry. Administration of PSG-1 significantly reduced apoptosis in the mouse brain in a dose-dependent manner. PSG-1-evoked reduction of apoptosis was associated with the decrease of MDA and GSSG contents, and the increase of SOD, CAT, GPx and GSH-Rd activities, and GSH contents...Continue Reading

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Citations

Jan 24, 2012·Journal of Agricultural and Food Chemistry·Wen-Juan LiMing-Yong Xie
Dec 17, 2014·Journal of the Science of Food and Agriculture·Lan ZhengLe Jia
Jul 8, 2011·Basic & Clinical Pharmacology & Toxicology·Karolin YanarEzel Uslu
Apr 4, 2012·Geriatrics & Gerontology International·Kalaiselvi Velayutham AnandPitchairaj Geraldine
Sep 2, 2015·Journal of Agricultural and Food Chemistry·Wen-Juan LiMing-Yong Xie
Oct 16, 2015·Critical Reviews in Food Science and Nutrition·Liqiao LiuMingyong Xie
Mar 19, 2013·International Journal of Biological Macromolecules·Kexue ZhuMingyong Xie
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Sep 9, 2015·Food & Function·Xiaojun Huang, Shaoping Nie
Jan 19, 2018·Aging and Disease·Jue WangJuan Feng
Apr 19, 2012·Phytotherapy Research : PTR·Qiang YuMing-Yong Xie
Aug 20, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Peng ChenBenhong Zhou
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zengenni LiangXing-Yao Xiong

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