Ganoderma lucidum total triterpenes prevent γ-radiation induced oxidative stress in Swiss albino mice in vivo

Redox Report : Communications in Free Radical Research
T P SminaK K Janardhanan

Abstract

The in vivo radio-protective effect of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst was evaluated using Swiss albino mice, by pre-treatment with total triterpenes for 14 days, followed by a whole body exposure to γ-radiation. The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and the level of reduced glutathione (GSH) were analysed in liver and brain homogenates. The extent of lipid and protein peroxidation was also estimated in liver and brain homogenates after irradiation. Protection of radiation-induced DNA strand breaks in peripheral blood lymphocytes and bone marrow cells was assessed using the comet assay. Total triterpenes were highly effective in reducing the levels of lipid peroxidation and protein oxidation to near normal values in both liver and brain tissues. Total triterpenes, when administered in vivo, were also found to be successful in restoring the antioxidant enzyme activities and GSH level in liver and brain of irradiated mice. Administration of total triterpenes, prior to radiation exposure, significantly decreased the DNA strand breaks. The results of the present study thus revealed the potential therapeutic use of Gano...Continue Reading

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Citations

Jan 19, 2018·Aging and Disease·Jue WangJuan Feng
Oct 27, 2017·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Graham Smith, Nicole Martinez
Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev
Sep 16, 2020·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Amit Alok, Paban K Agrawala

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