Abstract
Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditions for more consistent chemical composition. The medicinal properties of GL are attributable to its antioxidant and anti-inflammatory activities. We intended to assess the effect of GL in atherosclerosis, an arterial condition associated with chronic oxidative stress and inflammation, using a carotid-artery-ligation mouse model. Flow turbulence created in the ligated artery induces oxidative stress and neointimal hyperplasia, a feature of early atherogenesis. Daily oral GL prevented neointimal thickening 2 weeks after ligation. Moreover, the ganoderma triterpenoid (GT) crude extract isolated from GL abolished ligation-induced neointima formation. Mechanistically, endothelial dysfunction was observed 3 days after ligation before any structural changes could be detected. GTs alleviated the oxidative stress and restored the atheroresistent status of endothelium by inhibiting the induction of a series of atherogenic factors, including endothelin-1, von Willebrand factor, and monocyte...Continue Reading
References
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·S PervinL Nathan
Sep 10, 1999·Phytotherapy Research : PTR·M ZhuR C Li
Sep 19, 2007·Biotechnology Annual Review·Bojana BohLin Zhi-Bin
Aug 5, 2009·International Immunopharmacology·Shailesh DudhgaonkarDaniel Sliva
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Douglas NamHanjoong Jo
Jan 21, 2011·Physiological Reviews·Jeng-Jiann Chiu, Shu Chien
Aug 26, 2011·International Journal of Cardiology·N P SudheeshK K Janardhanan
Oct 19, 2011·Environmental Toxicology and Pharmacology·T P SminaT P A Devasagayam
Apr 24, 2013·Molecular Nutrition & Food Research·Qian-Yu KuokFan-E Mo
May 17, 2013·Expert Opinion on Emerging Drugs·Jeremy P BermanRobert S Rosenson
May 23, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chun-Ru ChengDe-An Guo
Jul 28, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Melissa W LiErnesto L Schiffrin
Aug 27, 2013·Journal of the American College of Cardiology·Angie GhattasEduard Shantsila
Nov 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qing XiaGaimei She
Jan 29, 2016·Redox Report : Communications in Free Radical Research·T P SminaK K Janardhanan
Feb 20, 2016·Circulation Research·Michael A Gimbrone, Guillermo García-Cardeña
Sep 14, 2016·European Journal of Haematology·Wolfgang Miesbach, Erik Berntorp
Dec 3, 2016·Nature Reviews. Cardiology·Neil RupareliaRobin P Choudhury
Citations
Mar 20, 2020·Journal of Food Biochemistry·Min Jeong Kim, Sung Keun Jung
Mar 21, 2019·Frontiers in Physiology·Jinzhao HeBaoxue Yang
Aug 11, 2020·BioMed Research International·Fahmi ShaherShaobo Zhou
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei-Ting ChangSheng-Nan Wu
Jan 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mano R MauryaShankar Subramaniam
Oct 30, 2020·International Journal of Environmental Research and Public Health·Rohaina Che ManMuhammad Dain Yazid
May 6, 2021·Food & Function·Dandan WangYajun Duan
May 17, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Yanhong LiChuan Qin
Aug 20, 2021·Journal of Food Biochemistry·Ki Kwang OhDong Ha Cho