Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation

Oxidative Medicine and Cellular Longevity
Pei-Ling HsuFan-E Mo

Abstract

Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditions for more consistent chemical composition. The medicinal properties of GL are attributable to its antioxidant and anti-inflammatory activities. We intended to assess the effect of GL in atherosclerosis, an arterial condition associated with chronic oxidative stress and inflammation, using a carotid-artery-ligation mouse model. Flow turbulence created in the ligated artery induces oxidative stress and neointimal hyperplasia, a feature of early atherogenesis. Daily oral GL prevented neointimal thickening 2 weeks after ligation. Moreover, the ganoderma triterpenoid (GT) crude extract isolated from GL abolished ligation-induced neointima formation. Mechanistically, endothelial dysfunction was observed 3 days after ligation before any structural changes could be detected. GTs alleviated the oxidative stress and restored the atheroresistent status of endothelium by inhibiting the induction of a series of atherogenic factors, including endothelin-1, von Willebrand factor, and monocyte...Continue Reading

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Citations

Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei-Ting ChangSheng-Nan Wu
Jan 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mano R MauryaShankar Subramaniam
Oct 30, 2020·International Journal of Environmental Research and Public Health·Rohaina Che ManMuhammad Dain Yazid
May 17, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Yanhong LiChuan Qin

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

NIS
Power
FlowJo
NIH ImageJ
Elements D

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