Gap junction intercellular communication and benzene toxicity

Chemico-biological Interactions
Edgar RivedalEdward Leithe

Abstract

Aberrant regulation of gap junction intercellular communication (GJIC) has been linked to several human diseases, including cancer and abnormal hematopoietic development. Benzene exposure has been shown to cause hematotoxicity and leukemia, but the underlying mechanisms involved remain unclear. We have observed that several metabolites of benzene have the ability to block gap junction intercellular communication. The ring-opened trans,trans-muconaldehyde (MUC) was found to be the most potent inhibitor of gap junction channels. MUC was found to induce cross-linking of the gap junction protein connexin43, which seemed to be responsible for the induced inhibition of GJIC. Glutaraldehyde, which has a similar molecular structure as MUC, was found to possess similar effects on gap junctions as MUC, while the mono-aldehyde formaldehyde shows lower potency, both as a connexin cross-linker, and as an inhibitor of GJIC. Both glutaraldehyde and formaldehyde have previously been associated with induction of leukemia and disturbance of hematopoiesis. Taken together, the data support a possible link between the effect of MUC on gap junctions, and the toxic effects of benzene.

References

Jul 1, 1989·Environmental Health Perspectives·R SnyderB D Goldstein
Jan 1, 1986·Environmental Mutagenesis·G L ErexsonA D Kligerman
Sep 30, 1985·Toxicology and Applied Pharmacology·G WitzB D Goldstein
Feb 1, 1980·Mutation Research·M HiteS Thornton
Jan 1, 1994·Archives of Toxicology·U PlappertH J Seidel
Jun 1, 1996·Carcinogenesis·H Yamasaki, C C Naus
Aug 14, 1998·Environmental Health Perspectives·M T Smith, L Zhang
Dec 26, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ludek BláhaMiroslav Machala
Jun 20, 2002·Critical Reviews in Toxicology·Robert Snyder
Aug 14, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Miroslav MachalaBrad L Upham
Aug 19, 2003·Ear and Hearing·Eugene H ChangRichard J H Smith
May 29, 2004·Mutation Research·John WhysnerElizabeth A Lax
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Chih-Jen WeiCecilia W Lo
Feb 4, 2005·Archives of Toxicology·Edgar Rivedal, Gisela Witz
Mar 30, 2005·Mutation Research·Errol ZeigerPamela Spencer
Sep 6, 2005·Environmental Health Perspectives·Vincent James CoglianoUNKNOWN Working Group for Volume 88
Dec 20, 2005·Biochimica Et Biophysica Acta·Marc MesnilMaria-Lucia Zaidan-Dagli
Apr 10, 2009·Stem Cells and Development·Brynjar FossOystein Bruserud

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Citations

Mar 19, 2011·Toxicology Letters·Xiao-Rong WuZong-Chun Yi
Jul 15, 2015·Journal of Cellular and Molecular Medicine·Kun GaoJian Yao
Oct 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Holly M Weaver-GuevaraArthur Greenberg
Jun 3, 2021·Cancers·Giovanna SpatariSebastiano Gangemi
May 1, 2012·Chemical Research in Toxicology·Liping WangQiang Ma

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