PMID: 8977159Dec 1, 1996Paper

Gap junction involvement in secretion: the pancreas experience

Clinical and Experimental Pharmacology & Physiology
P Meda

Abstract

1. Gap junctions and junction-mediated cell-to-cell communications are obligatory features of gland cells, whatever their secretory product is. 2. Studies on pancreatic islets and acinar cells indicate that cell-to-cell communication via gap junction channels is required for proper biosynthesis, storage and release of both insulin and amylase. 3. However, the endocrine and exocrine portions of the pancreas show opposite connexin (Cx) and coupling changes in relation to the activation and inhibition of their secretory functions. 4. These differences may be accounted for by the expression of Cx43 in pancreatic islets and of Cx26 and Cx32 in pancreatic acini. This alternative expression of connexin isoforms is also found in several other endocrine and exocrine glands. 5. These observations indicate that connexin-made channels play a central role in the control of secretory events.

References

Jul 1, 1979·Pflügers Archiv : European journal of physiology·N Iwatsuki, O H Petersen
Feb 1, 1992·Seminars in Cell Biology·N M Kumar, N B Gilula
Sep 1, 1990·The Journal of Clinical Investigation·P MedaL Orci
Mar 1, 1991·Neuron·M V BennettJ C Sáez
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P MedaL Orci
Jul 1, 1987·Physiological Reviews·O H Petersen, I Findlay
Jul 1, 1987·The Journal of Clinical Investigation·Y StefanL Orci
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F C SchuitD G Pipeleers
Aug 15, 1973·Experientia·L OrciA E Renold
Oct 15, 1984·Experientia·D Pipeleers
Jan 1, 1984·The Journal of Membrane Biology·G T EddlestoneE Rojas
May 1, 1984·The Journal of Cell Biology·S A Murray, W H Fletcher
Oct 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·P MedaE Rojas
Jun 1, 1981·Experimental Cell Research·P MedaL Orci
Dec 1, 1995·The Journal of Cell Biology·C VozziP Meda

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Citations

Oct 20, 2006·Molecular Biology of the Cell·Shalini MitraParmender P Mehta
Nov 6, 2008·Acta Physiologica·M Rupnik
Feb 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fiona HannerJános Peti-Peterdi
Jul 11, 2002·Biological Chemistry·Klaus WilleckeGoran Söhl
Jan 8, 2000·Microvascular Research·K Hwan Seul, E C Beyer
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F StümpelK Jungermann
May 1, 2012·European Journal of Pharmacology·Tsuyoshi MatsumotoKoutaro Yokote
Sep 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Levin, M Mercola
Nov 28, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shing-Ming ChengMichael Levin
Dec 1, 1996·Clinical and Experimental Pharmacology & Physiology·D C Spray
Mar 26, 2005·Canadian Journal of Physiology and Pharmacology·A R LeiteC B Collares-Buzato
Dec 17, 2008·American Journal of Physiology. Renal Physiology·Jian YaoMasanori Kitamura
Sep 25, 2003·Physiological Reviews·Juan C SaezEric C Beyer
Aug 13, 1998·Glia·R Dermietzel, D C Spray
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Jian YaoTakashi Oite

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