Gap junction particle density of horizontal cells in goldfish retinas lesioned with 6-OHDA

The Journal of Comparative Neurology
W H BaldridgeR G Miller

Abstract

The I1 dopaminergic interplexiform cells of the fish retina are believed to modulate horizontal cell coupling by increasing gap junction resistance. Dopamine also modulates the morphology of horizontal cell gap junctions and mimics the effects of light adaptation. To determine whether the light-dependent changes in gap junction morphology are due to endogenous dopamine release, horizontal cell gap junctions were studied in goldfish retinas lacking dopaminergic neurons. Dopaminergic interplexiform cells were destroyed by intraocular injections of 6-hydroxydopamine in both eyes. After lesioning, fish were treated in one of four ways: (1) light-adapted, (2) dark-adapted (1 hour), (3) light-adapted and given an intraocular injection of dopamine, or (4) dark-adapted (1 hour) and injected with dopamine. The effectiveness of lesioning was evaluated by autoradiographic detection of [3H]-dopamine uptake in the retina of one eye. Retinas in which lesioning of the contralateral eye was deemed effective were processed for freeze-fracture electron microscopy and the particle density of horizontal cell gap junctions determined. Lesioned retinas, whether light- or dark-adapted, had elevated horizontal cell soma gap junction particle densities...Continue Reading

References

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Citations

Feb 1, 1992·Neurochemistry International·M B Djamgoz, H J Wagner
Dec 1, 1996·Vision Research·N Vardi, R G Smith
Jan 22, 1994·Proceedings. Biological Sciences·E C HampsonD I Vaney
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Sep 15, 1990·The Journal of Comparative Neurology·D K Vaughan, E M Lasater

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