Gap junctions with amacrine cells provide a feedback pathway for ganglion cells within the retina

Proceedings. Biological Sciences
Garrett T Kenyon, David W Marshak

Abstract

In primates, one type of retinal ganglion cell, the parasol cell, makes gap junctions with amacrine cells, the inhibitory, local circuit neurons. To study the effects of these gap junctions, we developed a linear, mathematical model of the retinal circuitry providing input to parasol cells. Electrophysiological studies have indicated that gap junctions do not enlarge the receptive field centres of parasol cells, but our results suggest that they make other contributions to their light responses. According to our model, the coupled amacrine cells enhance the responses of parasol cells to luminance contrast by disinhibition. We also show how a mixed chemical and electrical synapse between two sets of amacrine cells presynaptic to the parasol cells might make the responses of parasol cells more transient and, therefore, more sensitive to motion. Finally, we show how coupling via amacrine cells can synchronize the firing of parasol cells. An action potential in a model parasol cell can excite neighbouring parasol cells, but only when the coupled amacrine cells also fire action potentials. Passive conduction was ineffective due to low-pass temporal filtering. Inhibition from the axons of the coupled amacrine cells also produced osci...Continue Reading

References

Jun 8, 1991·The Journal of Comparative Neurology·C UsaiS Bisti
Apr 1, 1987·The Journal of Physiology·S A Lipton, D L Tauck
Jan 8, 1988·The Journal of Comparative Neurology·A P Mariani, L B Hersh
Feb 1, 1988·The Journal of Physiology·J M CrookA Valberg
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E Kaplan, R M Shapley
Sep 22, 1987·The Journal of Comparative Neurology·M A Koontz, A E Hendrickson
Feb 1, 1983·Journal of Neurophysiology·D N Mastronarde
Nov 17, 1995·Science·M MeisterD A Baylor
Jan 1, 1995·Vision Research·L J Croner, E Kaplan
Dec 1, 1994·Vision Research·B B LeeJ Kremers
Jan 1, 1993·Annual Review of Neuroscience·W H Merigan, J H Maunsell
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M Meister
Feb 26, 1996·The Journal of Comparative Neurology·K K GhoshP R Martin
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·M RappI Segev
Jul 14, 1997·The Journal of Comparative Neurology·D Xin, S A Bloomfield
Jan 20, 1957·The Journal of General Physiology·H K HARTLINE, F RATLIFF

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Citations

Aug 10, 2006·Biological cybernetics·Greg J StephensGarrett T Kenyon
Aug 2, 2008·Journal of Computational Neuroscience·Adrien Wohrer, Pierre Kornprobst
Oct 24, 2002·Visual Neuroscience·David W MarshakWendy C Perryman
Feb 14, 2006·Visual Neuroscience·Franklin R AmthorNorberto M Grzywacz
Sep 11, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Oliver Krüger
May 25, 2007·Neural Computation·Jeremy A Miller, Garrett T Kenyon
Sep 8, 2010·The Journal of Physiology·Edward H HuStewart A Bloomfield
Feb 7, 2007·IEEE Transactions on Neural Networks·Andrzej W PrzybyszewskiChristopher M Wilson
Oct 16, 2004·IEEE Transactions on Neural Networks·Garrett T KenyonDavid W Marshak
Jan 15, 2013·Progress in Retinal and Eye Research·Béla VölgyiRóbert Gábriel
Apr 12, 2016·Scientific Reports·Timothée MasquelierPierre Kornprobst
Jun 7, 2017·Vision Research·Sayon RoyRemington Lim
Nov 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kaushambi RoyStewart A Bloomfield
Dec 14, 2018·Frontiers in Cellular Neuroscience·Orsolya KántorBéla Völgyi
Feb 24, 2004·Visual Neuroscience·Garrett T KenyonDavid W Marshak
Dec 18, 2019·The Journal of Comparative Neurology·Sara S PattersonDavid W Marshak
Jul 23, 2021·PloS One·Anastasiia Vlasiuk, Hiroki Asari

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