Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster

Pesticide Biochemistry and Physiology
Ebenezer Olatunde FarombiMathew Terwase Awunah

Abstract

Rotenone, a naturally occurring and commonly used pesticide, has been established as a model for inducing Parkinson's Disease (PD) in rodents. Kolaviron is a biflavonoid complex from Garcinia kola seeds with anti-oxidative and anti-inflammatory properties. Here, we evaluated the ameliorative role of Kolaviron on rotenone-induced toxicity in Drosophila melanogaster. Flies for longevity study were exposed to Kolaviron (100-500mg/kg diet) throughout the lifespan. For biochemical study, Groups A, B and C flies were treated with ethanol (2.0%, control, vehicle), Kolaviron (200mg/kg diet) and rotenone (250μM) respectively. Flies in Group D were co-treated with both rotenone (250μM) and Kolaviron (200mg/kg diet) for 7days. Subsequently, selected markers of antioxidant status, inflammatory and neurotoxicity were evaluated in the flies. The results from longevity experiment showed that Kolaviron (200, 100, 300 and 400mg/kg) extended lifespan of flies by 38.2%, 20.6%, 11.8% and 2.9% respectively. Also, Kolaviron attenuated rotenone-induced inhibition of catalase, glutathione-S-transferase and acetylcholinesterase activities and depletion of total thiols content in flies. Moreover, Kolaviron prevented rotenone-induced increases in hydroge...Continue Reading

Citations

Jan 16, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Afolabi C AkinmoladunM Tolulope Olaleye
Aug 25, 2020·Journal of Biochemical and Molecular Toxicology·Fatemeh YarmohammadiGholamreza Karimi
Nov 27, 2019·Experimental Biology and Medicine·Amos O AbolajiEbenezer O Farombi
Aug 17, 2020·Scientific Reports· RahulYasir Hasan Siddique
Sep 10, 2020·Toxicology Research·Amos Olalekan AbolajiEbenezer Olatunde Farombi
Feb 7, 2020·Toxicology Reports·Amos O AbolajiEbenezer O Farombi
Mar 9, 2021·Critical Reviews in Food Science and Nutrition·Georg SandnerJulian Weghuber
Jun 7, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Omolola A AdesanoyeAdeola O Adedara
Oct 22, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Thilaga Thirugnanam, Kirankumar Santhakumar

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