Garland-pattern postinfectious glomerulonephritis with IgA-dominant deposition

CEN Case Reports
Makoto KannoTsuyoshi Watanabe

Abstract

A histological subtype of acute postinfectious glomerulonephritis (APIGN), the garland pattern, is identified not only by characteristic histological findings, but also by severe clinical course as compared with typical APIGN. However, since the morbidity of APIGN has decreased globally, there have been few reports on this disease form in developed countries during the last two decades. Herein, we report a case of adolescent garland-pattern APIGN with IgA-dominant deposits, presenting with severe nephrotic syndrome and protracted hematuria and proteinuria. We also review the clinical and histological features of 13 previously reported cases in Japan and compare them with our present case. In our review, we confirmed IgA deposition in at least three of these patients, in whom urinary protein excretion tended to be greater than those patients without IgA. Greater awareness of this condition is necessary to ensure appropriate follow-up of the clinical course of patients with garland-pattern APIGN with IgA deposition.

References

Dec 6, 1997·Archives of Disease in Childhood·A SarkissianE Leumann
Jul 10, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriella MoroniClaudio Ponticelli
Dec 23, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ximena BerríosIngrid Riedel
Dec 24, 2003·Human Pathology·Samih H NasrVivette D D'Agati
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Nobuyuki YoshizawaMichael D P Boyle
Oct 29, 2005·The Lancet Infectious Diseases·Jonathan R CarapetisMartin Weber
Jan 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazuhide SuyamaHitoshi Suzuki
Aug 1, 2008·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe, James M Musser
Apr 23, 2009·Nature Reviews. Nephrology·Talerngsak KanjanabuchSomchai Eiam-Ong
Nov 6, 2010·Journal of the American Society of Nephrology : JASN·Samih H NasrVivette D D'Agati
Oct 31, 2012·Korean Journal of Pathology·Tai Yeon KooMoon Hyang Park

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Citations

Jan 24, 2019·Journal of Clinical Medicine·Alejandra Oralia Orozco GuillénMagdalena Madero

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