PMID: 14567929Oct 22, 2003Paper

Garlic attenuates hypercholesterolemic risk factors in olive oil fed rats and high cholesterol fed rats

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Kothapa N. ChettySushil K. Jain

Abstract

This study was undertaken to compare the effects of garlic (G) on hypercholesterolemic risk factors in rats fed with corn oil (C) or olive oil (O) with and without cholesterol (Ch) enrichment in the diet. Male Sprague-Dawley rats (n=6 per group) were fed semi-purified diets containing 5% oil with or without cholesterol (Ch) or garlic (G) for 21 days. In the C fed rats, addition of dietary Ch, there was a redistribution of Ch from HDL to LDL class. In contrast, 1% Ch added to O diets produced a 4-fold increase in serum Ch compared with levels in rats fed O without Ch. This was associated with a 14-fold increase in LDL Ch and a 7-fold decrease in HDL Ch levels. Addition of 2% G had no effect on the distribution of serum Ch between HDL and LDL Ch in C+Ch fed rats, but in O+Ch fed rats, G halved the increase in serum Ch and LDL and attenuated the decrease in serum HDL by 23%. The results suggest that the dietary O regulated the levels of serum in Ch loaded rats. G attenuated serum Ch in O fed rats and decreased serum risk factors, both total Ch and LDL-C ratio and LDL-Ch/HDL-Ch ratio.

References

Aug 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R P Mensink, M B Katan
Jan 1, 1992·Nutrition and Cancer·C IpG S Stoewsand
Sep 1, 1990·International Journal of Epidemiology·J R BanegasF Villar
Aug 1, 1981·Archives of Internal Medicine·T GordonT R Dawber
Apr 1, 1994·Journal of Nutritional Science and Vitaminology·Y F Lu, H L Wu
Jun 1, 1993·The American Journal of Medicine·A K JainF G McMahon
Jun 9, 1999·Journal of Nutritional Science and Vitaminology·H TakeuchiH Takeuchi
Sep 23, 2000·Annals of Internal Medicine·C StevinsonE Ernst
Oct 29, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·B H Cho, S Xu

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Citations

Jun 1, 2011·Nutrition Research Reviews·S V RanaR P Ola
Sep 25, 2015·International Journal of Food Sciences and Nutrition·Ageliki I KatsarouNikolaos K Andrikopoulos
Sep 27, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Kothapa N ChettySrikrishna N Chetty
Jul 25, 2018·Recent Patents on Food, Nutrition & Agriculture·Kanza A AwanHafiz A R Suleria
Feb 18, 2006·The Journal of Nutrition·Martha ThomsonMuslim Ali

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