Garlic-derived anticancer agents: structure and biological activity of ajoene

BioFactors
Catherine H KaschulaM Iqbal Parker

Abstract

Garlic has been used throughout the centuries to treat infections, heart disease, and cancer. Ajoene is one of the main compounds formed from heating crushed garlic as a mixture of E- and Z-isomers (E- and Z-4,5,9-trithiadodeca-1,6,11-triene 9-oxide). Ajoene possesses a broad spectrum of biological activities that include anticancer activity. It's cytotoxicity towards cancer cells is postulated to occur via an apoptotic mechanism involving activation of the mitochondrial-dependent caspase cascade. Structure-activity studies on ajoene and ajoene analogues have revealed that the Z-isomer is moderately more active than the E-isomer at inhibiting in vitro tumor cell growth, suggesting that specific protein interactions may be important. Substitution of the terminal end allyl groups in ajoene for alkyl, aromatic, or heteroaromatic groups produces some analogs with superior in vitro anticancer activity to ajoene, opening up the way to developing ajoene-based anticancer agents.

References

Aug 1, 1992·Planta medica·C Egen-SchwindF H Kemper
Jan 1, 1989·European Biophysics Journal : EBJ·J C DebouzyR Apitz-Castro
Nov 6, 1989·Biochimica Et Biophysica Acta·Y GargouriR Verger
Nov 26, 1986·Biochemical and Biophysical Research Communications·R Apitz-CastroM K Jain
Jun 1, 1994·Planta medica·S NagaeY Higashi
Jan 1, 1996·Medicinal Research Reviews·K C Agarwal
Dec 1, 1996·Bioscience, Biotechnology, and Biochemistry·K IshikawaA Suzuki
Mar 10, 2001·The Journal of Nutrition·H AmagaseY Itakura
Mar 10, 2001·The Journal of Nutrition·A T Fleischauer, L Arab
Nov 6, 2002·Nutrition and Cancer·Min LiJeanne Leung-Tack
Nov 27, 2002·Bioscience, Biotechnology, and Biochemistry·Tomoaki NishikawaTsuchiyoshi Fujino
Feb 21, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E GermainC Teyssier
May 21, 2003·Archives of Dermatological Research·C M L J TilliH A M Neumann
Aug 4, 2005·Journal of Agricultural and Food Chemistry·Larry D Lawson, Christopher D Gardner
Jun 24, 2006·Cancer Letters·Yogeshwer Shukla, Neetu Kalra
May 25, 2007·Fundamental & Clinical Pharmacology·Jerome TerrassonChristian Davrinche
Jun 16, 2007·Organic & Biomolecular Chemistry·Ute MünchbergClaus Jacob
Sep 9, 2008·Bioorganic & Medicinal Chemistry Letters·Roger HunterThozama Qwebani

❮ Previous
Next ❯

Citations

Feb 22, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mansoor ForoughiPaul Steinbok
Oct 13, 2012·Journal of Medicinal Food·Da Yeon LeeJae-Ha Ryu
Feb 9, 2012·Antimicrobial Agents and Chemotherapy·Tim Holm JakobsenMichael Givskov
Jan 15, 2014·World Journal of Gastroenterology : WJG·Hong-Bing MaZheng-Li Di
Oct 19, 2013·BMC Complementary and Alternative Medicine·Ji Hee JeongHo Jin Heo
Apr 17, 2012·Natural Product Reports·Malte GerschStephan A Sieber
Jul 28, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jee Won HwangYong Kee Kim
Jul 25, 2015·Molecular Carcinogenesis·Catherine H KaschulaM Iqbal Parker
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter RoseYi-Zhun Zhu
Jun 13, 2020·The Journal of Biological Chemistry·Hannah ValentinoPablo Sobrado
Dec 5, 2020·Molecular Nutrition & Food Research·Jessica K HitchcockCatherine H Kaschula
May 15, 2021·Frontiers in Oncology·Mahshad SarvizadehHamed Mirzaei
Aug 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Najwan JubairAyesha Fatima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.