Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice

International Immunopharmacology
Xiaoyan JiangJi-Min Cao

Abstract

Diallyl trisulfide (DATS), a natural agent derived from garlic, has been tested for its antigastric cancer activities in various preliminary studies. However, more systematic pharmacodymatic (PD) and mechanistic evaluations are clearly needed. The aim of this study was to investigate the antitumor effects of DATS in the treatment of human gastric cancer cell SGC-7901 both in vitro and in vivo using widely recommended study procedures. DATS suppressed cancer cells proliferation and induced cell cycle arrest accompanied by an increase in the expressions of cyclin A2 and cyclin B1 in SGC-7901 cancer cells. DATS also caused an increase in apoptotic cell death, which involved in accumulations of bax, p53, and cytochrome C and reduction of Bcl-2 expressions. Besides, activation of JNK, ERK and p38 phosphorylation in DATS-treated cells suggested that mitogen-activated protein kinase (MAPKs) pathways were involved in DATS-induced apoptosis. Meanwhile, DATS significantly inhibited tumor growth and promoted tumor apoptosis in a xenograft model of gastric cancer cell SGC-7901. DATS inhibited tumor migration and invasion by modulating MMP9 and E-cadherin protein expressions. In addition, DATS treatment evidently increased the cytokine secr...Continue Reading

Citations

Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiuchen QiZhongxi Zhao
Mar 25, 2019·Journal of Cancer Research and Clinical Oncology·Andrea KapinovaJan Danko
Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Timothy OmaraMargaret Chepkemoi Koske
Jun 6, 2018·Journal of Experimental & Clinical Cancer Research : CR·Li-Dong ZuGuo-Hui Fu
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter RoseYi-Zhun Zhu
Oct 7, 2020·Journal of Ethnopharmacology·Ilyass Alami Merrouni, Mostafa Elachouri
Jun 2, 2021·Critical Reviews in Food Science and Nutrition·Xiaoming LuLi Ningyang
Nov 4, 2020·Journal of Agricultural and Food Chemistry·Jinxin XieRi-Yuan Tang
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arijit MondalAnupam Bishayee
Aug 24, 2021·Frontiers in Molecular Biosciences·Huichen ZhaoXiao-Bing Chen

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