Gas chromatographic analysis of therapeutic concentrations of maprotiline in serum, using flame-ionization detection

Journal of Chromatography
S Kärkkäinen, E Seppälä


For the measurement of the tetracyclic antidepressant maprotiline in human serum, a gas chromatographic method with flame-ionization detection has been developed. The assay specifications obtained are as follows: a precision (C.V) of 3.5-6.4%, and a relative recovery of 97-109% using amitriptyline as internal standard. The sensitivity of the assay from serum was 40 nmol/l. The applicability of the method has been shown by measuring steady-state serum levels of five inpatients. The steady-state serum levels of maprotiline given at a daily dosage of 75 mg varied from 272 to 570 nmol/l.


Sep 1, 1978·Clinical Pharmacology and Therapeutics·G Boëthius, F Sjöqvist
Jun 21, 1979·Psychopharmacology·D S RobinsonK R Lamborn
Sep 1, 1977·Clinical Pharmacology and Therapeutics·J T Biggs, V E Ziegler
Nov 27, 1978·European Journal of Clinical Pharmacology·S VandelR Volmat
Jan 1, 1979·Therapeutic Drug Monitoring·P J Orsulak, J J Schildkraut
Mar 1, 1978·Clinical Pharmacology and Therapeutics·R BraithwaiteS Dawling
Mar 1, 1976·Clinical Pharmacology and Therapeutics·L F GramJ Christiansen
Dec 1, 1977·Clinical Pharmacology and Therapeutics·D J KupferP Coble
Nov 12, 1975·Journal of Chromatography·U P GeigerW Riess
Jun 17, 1972·Lancet·R A BraithwaiteA Coppen

❮ Previous
Next ❯


Aug 4, 1997·Forensic Science International : Synergy·T Keller, U Zollinger
May 10, 1985·Journal of Chromatography·T R Norman, K P Maguire

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.