Gas chromatographic-mass fragmentographic determation of "steady-state" plasma levels of imipramine and desipramine in chronically treated patients

Journal of Chromatography
G BelvedereC Pantarotto

Abstract

A sensitive and specific method for the simultaneous determination of imipramine and desipramine in the blood plasma of depressed patients under treatment that involves separation by gas chromatography and detection by mass fragmentography is described. Concentrations were determined by focusing the mass spectrometer upon the ions at m/e 280 and 235 for imipramine and 308, 236 and 114 for desipramine (N-acetyl derivative), while promazine was used as the internal standard (ions at m/e 284 and 238). Determinations are possible at levels as low as 10 ng/ml in plasma.

References

Jul 6, 1971·Annals of the New York Academy of Sciences·P L MorselliS Garattini
Jan 1, 1969·Psychopharmacologia·J Christiansen, O J Rafaelsen
Jul 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·S R HarrisA A Manian

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Citations

Dec 31, 1975·Psychopharmacologia·L VereczkeyP L Morselli
Nov 11, 2003·Clinical Pharmacokinetics·David R P Guay
Feb 1, 1980·Journal of Clinical Pharmacology·M A GagnonR Dugal
Sep 1, 1982·The Journal of Pharmacy and Pharmacology·A H Beckett, A J Hutt
Apr 30, 1982·Journal of Chromatography·J C CraigT L Nguyen
May 10, 1985·Journal of Chromatography·T R Norman, K P Maguire

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