Gas chromatographic-mass spectrometric determination of beta 2-agonists in postmortem blood: application in forensic medicine

Journal of Chromatography. B, Biomedical Applications
F J Couper, O H Drummer

Abstract

A solid-phase extraction procedure is described for the simultaneous determination of terbutaline, salbutamol and fenoterol in human postmortem whole blood, using gas chromatography-electron impact mass spectrometry. The limit of quantitation in 1 ml of blood was 1 ng/ml for all analytes. A linear response was observed over the concentration ranges tested, covering both low and high concentrations of each drug. The recoveries in postmortem blood were: terbutaline, 88%; salbutamol, 86%; fenoterol, 92%; orciprenaline (internal standard), 86%. Coefficients of variations for both intra-assay precision and inter-assay reproducibility ranged between 2.2 and 13.0% for all analytes. This method is sensitive and selective, and has been applied successfully to over 60 postmortem blood specimens.

Citations

Oct 18, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lúcia DamascenoJordi Segura
Aug 8, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·John G ElliotAlan L James
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·M J AbramsonUNKNOWN Victorian Asthma Mortality Study Group
Apr 23, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Md FaiyazuddinRoop Krishen Khar
Jul 12, 2008·Journal of Pharmaceutical and Biomedical Analysis·Danuta SilukIrving W Wainer
Dec 9, 2010·Human & Experimental Toxicology·Alexandra BoucherJacques Descotes

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