PMID: 8939011Nov 11, 1996Paper

Gas chromatographic procedures for determination of ethanol in postmortem blood using t-butanol and methyl ethyl ketone as internal standards

Forensic Science International : Synergy
C L O'NealA Poklis

Abstract

Three gas chromatographic procedures for the determination of ethanol in postmortem blood using alternative internal standards to n-propanol are presented: a direct injection procedure using t-butanol, and two headspace methods using t-butanol and methyl ethyl ketone. t-Butanol and methyl ethyl ketone were well resolved from ethanol, acetone, methanol and other commonly observed putrefactive volatiles using direct injection or headspace analysis. CVs for the direct injection method were below 5% for ethanol and below 10% for the other volatiles. The lower limits of detection (LOD) were 25-50 mg/L. The CVs for the headspace methods were below 5% for ethanol and below 6% for the other volatiles. The LODs were 10 mg/L using either t-butanol or methyl ethyl ketone as internal standards. The use of t-butanol or methyl ethyl ketone as alternatives to n-propanol avoids the possibility of error in the quantitation of ethanol due to the presence of n-propanol and allows for the identification of other volatiles that may aid in distinguishing antemortem ingestion from postmortem production of ethanol.

References

Sep 1, 1982·Forensic Science International : Synergy·R NanikawaK Hamada
Mar 1, 1996·The American Journal of Forensic Medicine and Pathology·C L O'Neal, A Poklis

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Citations

Mar 5, 2013·Forensic Science, Medicine, and Pathology·Luke N RoddaOlaf H Drummer
Jul 10, 2013·Forensic Science International : Synergy·Jessica L Westland, Frank L Dorman
Jan 7, 1998·The American Journal of Cardiology·M FerrellD M Gilligan
Aug 24, 1999·Journal of Chromatography. a·S Strassnig, E P Lankmayr
May 17, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dariusz ZubaManfred Reichenbächer
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Frank Musshoff
Jul 23, 2005·International Journal of Toxicology·Kallirroe ZiavrouTheodore G Vougiouklakis
Jun 20, 2006·Forensic Science International : Synergy·Fredrik C Kugelberg, Alan Wayne Jones
Oct 7, 2004·Journal of Toxicology. Clinical Toxicology·Christopher P HolstegeAlphonse Poklis
Jun 9, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·K Watanabe-SuzukiO Suzuki
Jun 15, 1997·Analytical Chemistry·T A Brettell, R Saferstein
Apr 25, 2007·Forensic Science International : Synergy·Vassiliki A BoumbaTheodore Vougiouklakis

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