Gas chromatography-microchip atmospheric pressure chemical ionization-mass spectrometry

Analytical Chemistry
Pekka OstmanRisto Kostiainen

Abstract

An atmospheric pressure chemical ionization (APCI) microchip is presented for combining a gas chromatograph (GC) to a mass spectrometer (MS). The chip includes capillary insertion channel, stopper, vaporizer channel, nozzle and nebulizer gas inlet fabricated on the silicon wafer, and a platinum heater sputtered on a glass wafer. These two wafers are joined by anodic bonding creating a two-dimensional version of an APCI microchip. The sample from GC is directed via heated transfer line capillary to the vaporizer channel of the APCI chip. The etched nozzle forms narrow sample plume, which is ionized by an external corona discharge needle, and the ions are analyzed by a mass spectrometer. The GC-microchip APCI-MS combination provides an efficient method for qualitative and quantitative analysis. The spectra produced by microchip APCI show intensive protonated molecule and some fragmentation products as in classical chemical ionization for structure elucidation. In quantitative analysis the GC-microchip APCI-MS showed good linearity (r(2) = 0.9989) and repeatability (relative standard deviation 4.4%). The limits of detection with signal-to-noise ratio of three were between 0.5 and 2 micromol/L with MS mode using selected ion monito...Continue Reading

References

Nov 13, 2004·Analytical Chemistry·Pekka OstmanRisto Kostiainen
Nov 13, 2004·Analytical Chemistry·Tiina J KauppilaRisto Kostiainen
Mar 19, 2005·European Journal of Mass Spectrometry·Daniel J Goebbert, Paul G Wentold
Sep 28, 2005·Journal of the American Society for Mass Spectrometry·Charles N McEwen, Richard G McKay

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Citations

Oct 31, 2008·Analytical and Bioanalytical Chemistry·Hai-Fang Li, Jin-Ming Lin
Dec 17, 2009·Journal of the American Society for Mass Spectrometry·Laura LuosujärviTapio Kotiaho
Jul 19, 2008·Mass Spectrometry Reviews·Xiaojun FengBi-Feng Liu
Jun 11, 2009·Mass Spectrometry Reviews·Tiina SikanenRaimo A Ketola
Jan 31, 2007·Journal of Mass Spectrometry : JMS
Oct 26, 2007·Lab on a Chip·Sander Koster, Elisabeth Verpoorte
Sep 18, 2009·Rapid Communications in Mass Spectrometry : RCM·Pekka Keski-RahkonenSeppo Auriola
May 4, 2007·Lab on a Chip·Ville SaarelaSami Franssila
Jan 20, 2011·Mass Spectrometry Reviews·P TerrierW Buchmann
Aug 27, 2010·Rapid Communications in Mass Spectrometry : RCM·Jaroslav PólRisto Kostiainen
Mar 27, 2007·Analytical Chemistry·Jaroslav PólRisto Kostiainen
Oct 8, 2008·Analytical Chemistry·Nina BrennerRisto Kostiainen
Dec 30, 2006·Analytical Chemistry·Jiangjiang LiuJin-Ming Lin

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