Gas exchange after pulmonary thromboemoblization in dogs

Circulation Research
D R DantzkerJ B West


Gas exchange following experimental pulmonary thromboembolization was studied with an inert gas elimination technique in 17 dogs. Pulmonary arterial, systemic arterial, and expired gas concentrations of six gases infused intravenously were measured before embolization and 5, 10, 15, 30, 60, and 120 minutes after embolization. Distributions of ventilation-perfusion (VA/Q) ratios were derived from the measured concentrations. In all dogs, embolization caused an increase in blood flow and ventilation to VA/Q ratios less than 1. There were no lung units with VA/Q ratios between 10 and 100 before embolization, but, in two-thirds of the dogs, such regions developed after embolization. Ventilation to unperfused lung showed a transient increase of 2-6%. Radioisotope studies of lobes removed post-mortem indicated that thromboemboli rarely caused complete abolition of lobar blood flow. Pulmonary embolization did not cause arteriovenous shunts to appear. The hypoxemia caused by embolization could be accounted for by the changes in VA/Q distributions. Over the 2-hour period after embolization, lung function improved as the distributions partially returned toward the preembolization patterns.


Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J W Evans, P D Wagner
Jun 1, 1975·Journal of Applied Physiology·P D WagnerJ B West
Jul 1, 1975·Journal of Applied Physiology·S E Levy, D H Simmons
May 1, 1974·Journal of Applied Physiology·P D WagnerR B Laravuso
Apr 1, 1973·Journal of Applied Physiology·T HiroseM Stein
Jan 1, 1974·Journal of Applied Physiology·S E Levy, D H Simmons
May 1, 1974·Journal of Applied Physiology·P D WagnerJ B West
Apr 11, 1968·The American Journal of Physiology·R J AllgoodD C Sabiston
Mar 1, 1971·The Journal of Clinical Investigation·J E WilsonC B Mullins
Dec 1, 1969·The American Journal of Medicine·E R Kafer
Mar 1, 1970·The Annals of Thoracic Surgery·T V Thomas
Jul 1, 1969·Journal of Applied Physiology·S E LevyD H Simmons
Oct 1, 1965·The Journal of Clinical Investigation·S E LevyE D Robin
Nov 1, 1966·Archives of Surgery·G S KovacsF Gerbode
May 1, 1957·Journal of Applied Physiology·J W SEVERINGHAUS, M STUPFEL
May 1, 1961·Journal of Applied Physiology·J M CAHILLJ J BYRNE
Sep 1, 1961·The Journal of Clinical Investigation·D F HALMAGYI, H J COLEBATCH
Jan 1, 1961·Journal of Applied Physiology·J W SEVERINGHAUSJ WILLIAMS
May 1, 1961·The Journal of Clinical Investigation·E W SWENSONS V GUZMAN
May 1, 1964·Journal of Applied Physiology·J A NADELC R OLSEN
Jun 1, 1964·The American Journal of Physiology·D THOMASS Wessler
May 1, 1960·Journal of Applied Physiology·B B ROSS, L E FARHI


Jan 1, 1986·International Journal of Clinical Monitoring and Computing·P PaolettiC Giuntini
Nov 1, 1981·Canadian Anaesthetists' Society Journal·J C KayY Z Kadiri
May 1, 1980·Canadian Anaesthetists' Society Journal·Y Z KadiriW H Noble
Mar 1, 1983·Canadian Anaesthetists' Society Journal·R Martineau, W H Noble
Jan 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·John H ReidInternational Atomic Energy Agency Consultants' Group
Jan 1, 1979·Respiration Physiology·M P HlastalaB K Ross
Jul 14, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·C PermpikulR G Spragg
Jul 25, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jeffrey A KlineR A Seupal
Aug 4, 1984·British Medical Journal·G H BurtonP Vernon
Jan 1, 1990·The American Review of Respiratory Disease·K M Moser
Oct 1, 1979·The Journal of Clinical Investigation·D R Dantzker, J S Bower
Dec 17, 2005·AJR. American Journal of Roentgenology·Zafiria M MetafratziStauros C Efremidis
Jan 1, 1984·Intensive Care Medicine·M MeignanL Cinotti
Nov 16, 2011·Critical Care Clinics·Timothy A Morris
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Robert GoggsDaniel L Chan
Jun 30, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Francesca CucchiJann Mortensen
Jan 29, 2000·Annals of Emergency Medicine·Jeffrey A KlineE G Israel
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Aman JalaliR Rizi
Sep 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M C FischerR Rizi
Dec 1, 1982·Journal of Neurosurgery·A J PoppA B Malik
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
May 30, 2014·Journal of Occupational Health·Shuchi BhagiShashi Bala Singh
Jan 11, 2001·Acta Anaesthesiologica Scandinavica·P Neumann, G Hedenstierna
Feb 5, 2000·Journal of Applied Physiology·J Y TsangM P Hlastala
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alan E JonesJeffrey A Kline
Dec 14, 2004·Journal of Applied Physiology·John Y C TsangM P Hlastala

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

Canadian Anaesthetists' Society Journal
W H Noble, J C Kay
The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine
D A TibbuttG A Miller
© 2021 Meta ULC. All rights reserved