Gas exchange and cardiovascular kinetics with different exercise protocols in heart transplant recipients

Journal of Applied Physiology
Bruno GrassiPaolo Cerretelli

Abstract

Metabolic and cardiovascular adjustments to various submaximal exercises were evaluated in 82 heart transplant recipients (HTR) and in 35 control subjects (C). HTR were tested 21.5 +/- 25.3 (SD) mo (range 1.0-137.1 mo) posttransplantation. Three protocols were used: protocol A consisted of 5 min of rectangular 50-W load repeated twice, 5 min apart [5 min rest, 5 min 50 W (Ex 1), 5 min recovery, 5 min 50 W (Ex 2)]; protocol B consisted of 5 min of rectangular load at 25, 50, or 75 W; protocol C consisted of 15 min of rectangular load at 25 W. Breath-by-breath pulmonary ventilation (VE), O2 uptake (VO2), and CO2 output (VCO2) were determined. During protocol A, beat-by-beat cardiac output (Q) was estimated by impedance cardiography. The half times (t1/2) of the on- and off-kinetics of the variables were calculated. In all protocols, t1/2 values for VO2 on-, VE on-, and VCO2 on-kinetics were higher (i.e., the kinetics were slower) in HTR than in C, independently of workload and of the time post-transplantation. Also, t1/2 Q on- was higher in HTR than in C. In protocol A, no significant difference of t1/2 VO2 on- was observed in HTR between Ex 1 (48 +/- 9 s) and Ex 2 (46 +/- 8 s), whereas t1/2 Q on- was higher during Ex 1 (55 +/- 2...Continue Reading

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Citations

Nov 6, 2003·Medicine and Science in Sports and Exercise·Emma BorrelliBruno Grassi
Dec 1, 2012·Journal of Applied Physiology·Antonio CrisafulliAlberto Concu
Sep 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Daniel M HiraiDavid C Poole
Apr 8, 1999·Journal of Applied Physiology·M E Tschakovsky, R L Hughson
Nov 24, 1999·The American Journal of Physiology·N HayashiT Yoshida
Aug 5, 2006·Medicine and Science in Sports and Exercise·Francesca LanfranconiBruno Grassi
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Antonio CrisafulliPasquale Pagliaro
Jan 6, 2005·Medicine and Science in Sports and Exercise·Helge HebestreitRichard L Hughson
May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frédéric LadorGuido Ferretti
Mar 24, 2018·Medicine and Science in Sports and Exercise·Lucrezia ZuccarelliBruno Grassi
Oct 22, 2019·Medicine and Science in Sports and Exercise·Bruno GrassiMauro Marzorati
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May 22, 1998·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·M MeyerP Cerretelli
Oct 8, 2011·Journal of Applied Physiology·Matthew L GoodwinL Bruce Gladden
Feb 12, 2008·Journal of Applied Physiology·Claudio MarconiPaolo Cerretelli
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Feb 12, 2014·Thyroid : Official Journal of the American Thyroid Association·Francisco Zacaron WerneckMário Vaisman
Aug 15, 2021·European Journal of Applied Physiology·Timothée FontollietGuido Ferretti

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