PMID: 9556924Apr 29, 1998Paper

Gas exchange at rest during simulated altitude in patients with chronic lung disease

Archives of Medical Research
G Chi-Lem, Rogelio Pérez-Padilla

Abstract

To characterize the gasometric and oximetric response to simulated altitudes of 3,100 m and sea level of patients with Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) studied at 2,240 m above sea level. Consecutive stable patients with COPD and ILD were studied at the National Institute of Respiratory Diseases, a referral center for pulmonary diseases in Mexico City, and a healthy control group. The patients breathed room air (FIO2 = 0.21), for at least 15 min, then, a hypoxic mixture (FIO2 = 0.18, simulating 3,100 m), and finally, a hyperoxic mixture (FIO2 = 0.28, simulating sea level). Arterial blood gases and oxygen saturation were measured by a pulse oximeter at the end of each stage. Twelve patients with COPD, 13 patients with ILD and 11 healthy controls were studied. The PaCO2 and pH were constant in the three study stages in both groups of patients and controls. A slope of PaO2 vs. altitude of 9 Torr per Km was found for each of the study's patients, either by simple linear regression or multiple regression, which is identical to that previously obtained at sea level with COPD patients (Gong et al.). Oxygen desaturation per Km of altitude change was alinear, higher for the hypoxic than fo...Continue Reading

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