PMID: 3522115Jul 1, 1986

Gas exchange during mechanical ventilation and spontaneous breathing. Intermittent mandatory ventilation after open heart surgery

G WolffE Grädel


Pulmonary gas exchange rates in eight patients after open heart surgery were studied during weaning from the ventilator. We investigated continuous positive pressure ventilation (CPPV), intermittent mandatory ventilation (IMV) and spontaneous breathing with continuous positive airway pressure (CPAP). During each mode of ventilation we measured: CO2 production (VCO2), O2 consumption (VO2), cardiac output (CO), PaO2, Qs/QT and functional residual capacity (FRC). In addition, we analyzed in each single breath: tidal volume (VT), series dead space volume (Vds), alveolar ventilation, alveolar efficiency for CO2 elimination (alv eff CO2) and end-tidal CO2 concentration (FCO2et). We compared the results of CPPV, IMV and CPAP and the mandatory breaths (MB) with the spontaneous breaths (SB) measured during IMV. CO was low during CPPV, when the patient still deeply sedated; it was increased in IMV and remained constant in the following CPAP period. VCO2 and VO2 did not differ significantly when switching from IMV to CPAP; therefore, work due to breathing seemed not to be reduced by the mandatory breath during IMV. Oxygenation (PaO2, Qs/QT) did not change significantly when switching from one mode to the other. FRC was constant when chang...Continue Reading


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