Gas phase attachment of water and methanol to Ag(I) complexes with alpha-amino acids in an ion trap mass spectrometer

Rapid Communications in Mass Spectrometry : RCM
B A PereraM J Van Stipdonk

Abstract

Electrospray ionization was used to generate gas phase complexes of Ag+ with selected alpha-amino acids. Following storage (isolation without collisional activation) in an ion trap mass spectrometer, the mass spectra produced from the complexes of Ag+ with alpha-amino acids such as alanine, valine and tert-leucine contained peaks consistent with the formation of water or methanol molecule adduct ions. The same adduct ions were not present, however, in the mass spectra generated from the Ag+ complexes with phenylalanine, tyrosine and tryptophan following isolation and storage under similar conditions. For those complexes that showed reactivity, the uptake of water and methanol increased with longer storage times in the ion trap. A preliminary molecular modeling study using phenylalanine demonstrated that the aromatic ring coordinates the Ag+ ion, and the interaction between the metal ion and pi-system, in part, is assumed to prohibit the binding of water or methanol during isolation in the gas phase. This conclusion is supported by a comparison of the adduct formation by the Ag+ complexes with phenylalanine, 4-fluorophenylalanine and alpha-aminocyclohexanepropionic acid. In addition, collision induced dissociation experiments in...Continue Reading

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Citations

Mar 28, 2013·Journal of the American Society for Mass Spectrometry·Adam M Graichen, Richard W Vachet
Dec 4, 2003·Journal of the American Society for Mass Spectrometry·Michael Pikulski, Jennifer S Brodbelt
May 18, 2004·Journal of the American Society for Mass Spectrometry·Winnie ChienGary Groenewold
Dec 5, 2006·Journal of the American Society for Mass Spectrometry·Narciso CoutoBenedito J Costa Cabral
Jun 23, 2007·Journal of the American Society for Mass Spectrometry·Carolyn L MazzitelliJennifer S Brodbelt
Apr 16, 2002·Journal of the American Society for Mass Spectrometry·Tamer ShoeibK W Michael Siu
Nov 5, 2003·Journal of the American Society for Mass Spectrometry·Michael Van StipdonkDorothy Hanna
Mar 1, 2002·Rapid Communications in Mass Spectrometry : RCM·J M Barr, M J Van Stipdonk
Mar 23, 2010·Journal of Chromatography. a·Michal HolcapekMiroslav Lísa
Sep 25, 2003·Journal of Mass Spectrometry : JMS·V Anbalagan, M J Van Stipdonk
Jan 29, 2008·Rapid Communications in Mass Spectrometry : RCM·Narciso CoutoM Filomena Duarte
Jun 29, 2006·Rapid Communications in Mass Spectrometry : RCM·Athula B AttygalleEinar J Stauber
Sep 21, 2010·Journal of Mass Spectrometry : JMS·Chang-Ching ChanAthula B Attygalle
Nov 17, 2010·Rapid Communications in Mass Spectrometry : RCM·T Jayasekharan, N K Sahoo
Jun 24, 2011·Rapid Communications in Mass Spectrometry : RCM·Matthew J WoolleyRichard A J O'Hair
Sep 25, 2002·Journal of Mass Spectrometry : JMS·V AnbalaganM J Van Stipdonk
Aug 28, 2001·Journal of Mass Spectrometry : JMS
Oct 11, 2002·Journal of Mass Spectrometry : JMS·Adrian WeiszAsher Mandelbaum
Apr 13, 2017·Rapid Communications in Mass Spectrometry : RCM·Vítor S PintoNarciso Couto
Jan 9, 2007·Rapid Communications in Mass Spectrometry : RCM·Lianming Wu, David Q Liu
Jan 22, 2010·The Journal of Organic Chemistry·Frank DreiockerMathias Schäfer

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