Gas-phase chemistry of multiply charged bioions in analytical mass spectrometry.

Annual Review of Analytical Chemistry
Teng-Yi Huang, Scott A McLuckey

Abstract

Ion chemistry has long played an important role in molecular mass spectrometry (MS), as it is central to the use of MS as a structural characterization tool. With the advent of ionization methods capable of producing gaseous ions from large biomolecules, the chemistry of gaseous bioions has become a highly active area of research. Gas-phase biomolecule-ion reactions are usually driven by interactions with neutral molecules, photons, electrons, ions, or surfaces. Ion dissociation or transformation into different ion types can be achieved. The types of reaction products observed depend on the characteristics of the ions, the transformation methods, and the time frame of observation. This review focuses on the gas-phase chemistries of ions derived from the electrospray ionization of peptides, proteins, and oligonucleotides, with particular emphasis on their utility in bioanalysis. Various ion-transformation strategies, which further facilitate structural interrogation by converting ions from one type to another, are also summarized.

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Citations

Jan 17, 2012·Proteomics·Min-Sik Kim, Akhilesh Pandey
Jul 12, 2013·Chemistry : a European Journal·James D FletcherStephen D Price
Oct 23, 2014·Journal of the American Society for Mass Spectrometry·Zhou PengScott A McLuckey
Jun 19, 2012·Journal of Mass Spectrometry : JMS·John R StutzmanScott A McLuckey
May 17, 2017·Journal of the American Society for Mass Spectrometry·Sy-Chyi ChengJentaie Shiea
Jun 1, 2017·Journal of the American Society for Mass Spectrometry·Evelyn H WangKevin A Schug
Jun 1, 2017·Journal of the American Society for Mass Spectrometry·Sandilya V B GarimellaRichard D Smith
Dec 30, 2014·ACS Chemical Biology·Sophia Doll, Alma L Burlingame
Feb 18, 2015·Chemical Reviews·He HuangYingming Zhao

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Methods Mentioned

BETA
protein folding
glycosylation

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