Gas transfer and in vitro and in vivo blood compatibility of a fluorinated polyimide membrane with an ultrathin skin layer

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
H KawakamiS Kubota

Abstract

The authors have synthesized fluorinated polyimides to develop a novel membrane oxygenator combining excellent gas transfer and blood compatibility. Gas exchange membranes of fluorinated polyimides prepared by a dry/wet process showed an asymmetric structure and consisted of an ultrathin and defect-free skin layer supported by a porous substructure. The asymmetric polyimide membranes never incurred plasma leakage because of the defect-free skin layer of the membrane surface. The calculated, apparent defect-free skin layer thickness of the asymmetric membrane was approximately 20 nm. Carbon dioxide and oxygen transfer rates through the membranes were dramatically enhanced because of the ultrathin skin layer and were 96 and 64 times larger than those determined in currently available oxygenator polymer membranes, such as polydimethylsiloxane (PDMS). For the evaluation of in vitro blood compatibility, platelet adhesion and plasma protein adsorption on the polyimide membranes were measured by using scanning electron microscopic examination and an amino acid analyzer. Deformation and aggregation of platelets adherent to the membranes were not observed, and the number of platelets was 1.6 micrograms/cm2, which was one-sixth less than...Continue Reading

Citations

Apr 29, 2004·Artificial Organs·Motohiro NiwaSunao Kubota
Feb 3, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroyoshi Kawakami
Feb 9, 2002·Journal of Biomedical Materials Research·M KannoS Kubota
May 1, 2001·IEEE Transactions on Bio-medical Engineering·P J RouscheD R Kipke
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ángel E Mercado-PagánYunzhi Yang
Nov 19, 2003·Journal of Biomedical Materials Research. Part a·H KawakamiS Kubota
Dec 6, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangJoseph B Zwischenberger
Oct 6, 2004·Journal of Biomaterials Science. Polymer Edition·Akon HiguchiMariko Hara
Sep 1, 2005·Journal of Biomaterials Science. Polymer Edition·H KawakamiS Nagaoka
Jul 27, 2001·Journal of Biomaterials Science. Polymer Edition·M NiwaS Kubota

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