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Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

The Journal of Experimental Medicine

Nov 4, 2019

Sheng Shu LiShuo Yang

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Abstract

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in th...read more

Mentioned in this Paper

Blood Vessel
Cell Differentiation Process
Demyelination
Experimental Autoimmune Encephalomyelitis
Inflammation
Laboratory mice
T-Lymphocyte
Vitamin D Deficiency
Cytokine
Mice, Knockout
24
2
23
1
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Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

The Journal of Experimental Medicine

Nov 4, 2019

Sheng Shu LiShuo Yang

PMID: 31467036

DOI: 10.1084/jem.20190377

Abstract

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in th...read more

Mentioned in this Paper

Blood Vessel
Cell Differentiation Process
Demyelination
Experimental Autoimmune Encephalomyelitis
Inflammation
24
2
23
1

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Paper Details
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