PMID: 3768230Oct 1, 1986Paper

Gaseous homeostasis and the circle system. Factors influencing anaesthetic gas exchange

British Journal of Anaesthesia
C M Conway

Abstract

A mathematical model of a subject breathing from a circle system has been used to follow the course of anaesthetic uptake during the simulated administration of 60% nitrous oxide, 2% halothane and 2% methoxyflurane, under non-rebreathing conditions and with fresh gas flows to the circle system of between 8 and 0.25 litre min-1. Compared with the non-rebreathing state, the use of a circle system reduced the initial rate of increase of alveolar towards fresh gas anaesthetic concentration, and the rate of increase in body anaesthetic content. The degree of reduction became more marked as fresh gas flow was reduced, and as agents of increasing blood solubility were used. These effects of a circle system were influenced by the volume of the circle system and the composition of gas initially present within the system. When the circle system was in use there were increases in the magnitude of both the concentration effect and the second gas effect which were related to the magnitude of fresh gas flow. The use of a circle system augmented the effects of changes in cardiac output and reduced the effects of changes in ventilation on the alveolar concentrations of the anaesthetic. These influences of a circle system were also dependent on...Continue Reading

Citations

Jan 1, 1994·Anaesthesia·J P BengtsonO Stenqvist
Jul 1, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Patrick Magee
Jan 1, 1989·Annales Françaises D'anesthèsie Et De Rèanimation·P GauneauM Chauvin

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