Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

European Journal of Pharmacology
Paolo FagoneFerdinando Nicoletti

Abstract

Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions. These molecules include nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Abnormal production and metabolism of these molecules have been observed in several pathological conditions. The understanding of the role of gasotransmitters in the immune system has grown significantly in the past years, and independent studies have shed light on the effect of exogenous and endogenous gasotransmitters on immune responses. Moreover, encouraging results come from the efficacy of NO-, CO- and H2S -donors in preclinical animal models of autoimmune, acute and chronic inflammatory diseases. To date, data on the influence of gasotransmitters in immunity and immunopathology are often scattered and partial, and the scarcity of clinical trials using NO-, CO- and H2S -donors, reveals that more effort is warranted. This review focuses on the role of gasotransmitters in the immune system and covers the evidences on the possible use of gasotransmitters for the treatment of inflammatory conditions.

References

Jun 1, 1989·Journal of Cardiovascular Pharmacology·J M DeForrestE W Petrillo
Aug 1, 1995·Nature Medicine·J L ZweierP Kuppusamy
Feb 20, 1993·Lancet·S J MiddletonJ O Hunter
Jun 1, 1997·European Journal of Immunology·F NicolettiG Teti
Aug 28, 1997·Biochemical and Biophysical Research Communications·R HosokiH Kimura
Dec 31, 1997·Journal of Neuroimmunology·A H CrossT P Misko
Jan 15, 1998·FEBS Letters·P Ghafourifar, C Richter
Jun 6, 1998·The Journal of Biological Chemistry·A Tatoyan, C Giulivi
Oct 2, 1998·The Journal of Experimental Zoology·D G Searcy, S H Lee
Jul 13, 2000·Molecular Biotechnology·K BendtzenM Svenson
Jan 5, 2002·Expert Opinion on Investigational Drugs·R G TiltonR A Dixon
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark J Paul-ClarkMauro Perretti
Mar 21, 2002·The Journal of Pharmacy and Pharmacology·Lucyna Korzycka
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Azucena SalasJulián Panés
Sep 11, 2002·Cytokine & Growth Factor Reviews·William P Arend
Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Larry K Keefer
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Wanda NiedbalaFoo Y Liew
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Fiorucci, P Del Soldato
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M PerrettiR J Flower
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P K Moore, M Marshall
Jul 10, 2003·Lancet Neurology·Kenneth J Smith, Hans Lassmann
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun-Ock PaeHun-Taeg Chung
Apr 15, 2004·Journal of Neuroimmunology·Roberto FurlanGianvito Martino
Apr 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·Vincent LagenteCharles Advenier
May 7, 2004·The Journal of Pharmacology and Experimental Therapeutics·John L WallaceStefano Fiorucci
Jul 29, 2004·The Journal of Biological Chemistry·Ruiping SongLeo E Otterbein
Aug 28, 2004·The American Journal of Pathology·Matthias H KapturczakAnupam Agarwal
Oct 8, 2004·Clinical Pharmacology and Therapeutics·Paula ZacharowskiSharon O'Byrne
Jan 18, 2005·Biochemical and Biophysical Research Communications·Byung-Min ChoiHun-Taeg Chung
Jan 27, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Madhav BhatiaPhilip K Moore
Mar 9, 2005·British Journal of Pharmacology·Madhav BhatiaPhilip K Moore
May 3, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ling LiPhilip K Moore
May 4, 2005·Analytical Biochemistry·Jeannette E DoellerDavid W Kraus
Jun 22, 2005·Biochemical and Biophysical Research Communications·Muhammed YusufPhilip K Moore

❮ Previous
Next ❯

Citations

May 7, 2020·Antioxidants & Redox Signaling·Gabriel Gojon, Guillermo A Morales
Dec 17, 2018·Molecular Biology Reports·Yan-Ruide Li, Puneet Gupta
Nov 22, 2019·Frontiers in Oncology·Maria Sofia BasileMichele Reibaldi
Jul 18, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mohit KumarRajat Sandhir
Jul 12, 2020·Bulletin of Experimental Biology and Medicine·G I Lobov
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Masoud AkbariAlp Sener
Nov 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milica LazarevićĐorđe Miljković
May 21, 2020·Internal and Emergency Medicine·Riccardo Polosa, Grazia Caci
Sep 3, 2020·Immunology·Fei SunCong-Yi Wang
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Md Aejazur RahmanAdrie J C Steyn
Jul 3, 2021·International Journal of Molecular Sciences·Alicja NowaczykGrzegorz Grześk
Sep 3, 2021·Journal of Cell Science·Marielle SaclierGaëtan Juban

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.