Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Andrew K TrybaJan-Marino Ramirez

Abstract

Many rhythmic behaviors are continuously modulated by endogenous peptides and amines, but whether neuromodulation is critical to the expression of a rhythmic behavior often remains unknown, particularly in mammals. Here, we address this issue in the respiratory network that was isolated in spontaneously rhythmic medullary slice preparations from mice. Under control conditions, the respiratory network generates fictive eupneic activity. We hypothesized previously that this activity depends on two types of pacemaker neurons. The bursting properties of one pacemaker rely on the persistent sodium current (INa(p)) and are insensitive to blockade of calcium channels with cadmium (CI-pacemakers), whereas bursting mechanisms of a second pacemaker are sensitive to cadmium (CS-pacemakers) and the calcium-dependent nonspecific cation current blocker flufenamic acid. During hypoxia, fictive eupneic activity is supplanted by the neural correlate of gasping, which is proposed to depend only on CI-pacemakers. Because CI-pacemakers require endogenous activation of 5-HT2A receptors, we tested the hypothesis that 5-HT2A receptor activation is critical for gasping. Here, we demonstrate that fictive gasping and CI-pacemaker bursting were selective...Continue Reading

Citations

Apr 22, 2008·Journal of Computational Neuroscience·Wolfgang SteinHarald Wolf
Jun 2, 2012·Journal of Biological Physics·Jan-Marino RamirezSebastien Zanella
Aug 21, 2009·The New England Journal of Medicine·Hannah C Kinney, Bradley T Thach
Aug 23, 2011·Integrative and Comparative Biology·Henner KochJan-Marino Ramirez
Nov 16, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Charles J MarcuccilliJan-Marino Ramirez
Oct 2, 2009·Clinical and Experimental Pharmacology & Physiology·Fernando Peña
Apr 30, 2009·Annual Review of Pathology·Hannah C KinneyEugene E Nattie
Apr 19, 2008·Journal of Applied Physiology·Qiuli Liu, Margaret T T Wong-Riley
Feb 14, 2009·Journal of Applied Physiology·Walter M St-JohnJ C Leiter
Apr 18, 2013·PloS One·Alfredo J GarciaJan-Marino Ramirez
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atsushi Doi, Jan-Marino Ramirez
Mar 29, 2014·Journal of Computational Neuroscience·Amitabha BoseFarzan Nadim
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Aug 3, 2010·Forensic Science International : Synergy·Cornelius Courts, Burkhard Madea
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Jun 2, 2009·Respiratory Physiology & Neurobiology·David S PatersonDebra E Weese-Mayer
Jun 23, 2009·Respiratory Physiology & Neurobiology·Jean-Charles Viemari, Andrew K Tryba
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Jul 5, 2011·The European Journal of Neuroscience·Andrew K TrybaCharles J Marcuccilli

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