Gastric adenocarcinoma coexisting with a reddish semipedunculated polyp arising from Helicobacter pylori-negative normal gastric mucosa: a report of two cases

Clinical Journal of Gastroenterology
Yoshiaki IsonoHideki Toyoda

Abstract

We experienced two cases of adenocarcinoma coexisting with a hyperplastic polyp arising from Helicobacter pylori-negative normal gastric mucosa. The first case was of a 59-year-old man. Esophagogastroduodenoscopy revealed a protruding lesion measuring 4 mm in diameter on the greater curvature of the middle gastric body. The second case was of a 47-year-old man. Esophagogastroduodenoscopy showed a protruding lesion measuring 5 mm located at the greater curvature of the upper gastric body. The absence of atrophic changes in the entire gastric mucosa was confirmed endoscopically in both cases. Multiple H. pylori tests were all negative. Endoscopically, these protruding lesions appeared as reddish, semipedunculated polyps. Hyperplastic polyps were suspected based on white light endoscopic findings. Magnified endoscopy with narrow band imaging could not predict the coexistence of cancer. However, histopathological examination of the resected specimen revealed focal cancer at the surface of the gastric hyperplastic polyps. Considering the possibility that cancer may be coexisting in polyps, when reddish polyps are detected in H. pylori-negative normal gastric mucosa, it is important to perform a biopsy, or a careful follow-up endoscopy.

References

Feb 1, 1996·Digestive Diseases and Sciences·W L Zea-IriarteT Hattori
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Mar 16, 2002·Journal of Gastroenterology and Hepatology·Kazuyoshi YagiAtsuo Sekine
Nov 28, 2008·Digestive Diseases and Sciences·Richa Jain, Runjan Chetty
Apr 23, 2010·The American Journal of Surgical Pathology·Hiroya UeyamaSumio Watanabe
Nov 9, 2011·Helicobacter·Taiji MatsuoKazuaki Chayama
Dec 26, 2012·Expert Review of Gastroenterology & Hepatology·Seiji ShiotaYoshio Yamaoka
Jan 9, 2015·Clinical Journal of Gastroenterology·Yoshihiko OzakiYasunari Nakamoto
Mar 27, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yorimasa YamamotoMasahiro Igarashi
Nov 18, 2015·World Journal of Gastroenterology : WJG·Irene CoatiMassimo Rugge
Nov 12, 2016·World Journal of Gastroenterology : WJG·Adam Roman MarkowskiKatarzyna Guzinska-Ustymowicz
Dec 16, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shunsuke YoshiiTetsuo Takehara
May 3, 2018·Digestion·Akihiro YamadaShu Hoteya

❮ Previous
Next ❯

Citations

Mar 28, 2020·United European Gastroenterology Journal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Narihiro ShibukawaAkira Kaneko
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Narihiro ShibukawaAkira Kaneko
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Chiaki KusumotoKouhei Taniguchi
World Journal of Gastroenterology : WJG
Hiroya UeyamaSumio Watanabe
© 2022 Meta ULC. All rights reserved