Gastric adenocarcinoma of fundic gland type after Helicobacter pylori eradication: A case report

World Journal of Clinical Cases
Ya-Nan YuZi-Bin Tian

Abstract

Gastric adenocarcinoma of fundic gland type (GA-FG) has recently been proposed as a novel histological type of gastric cancer. We report a case of GA-FG in a 77-year-old Chinese woman with epigastric distention who was referred to endoscopy for the management of an incidentally found submucosal tumor-like elevated lesion in the lower part of the gastric body. The tumor occurred after Helicobacter pylori (H. pylori) eradication therapy without long-term use of proton pump inhibitors. Complete and curable removal of the tumor was performed by endoscopic submucosal dissection. Histopathological findings showed numerous cells with basophilic cytoplasm and mildly atypical nuclei-like chief cells of the fundic gland. The tumor was observed to have the so-called "endless glands" pattern of the well-differentiated mixed phenotype. A safe resection margin without lymphatic and venous invasion was observed. As the tumor occurred after H. pylori eradication therapy, it is unknown whether there was a relationship with H. pylori eradication. The patient will be followed up by periodic gastroscopic observation. In conclusion, we report a case of GA-FG after H. pylori eradication therapy without long-term proton pump inhibitors use. Further a...Continue Reading

References

Jul 6, 2007·Pathology International·Tetsuya TsukamotoMasae Tatematsu
Apr 23, 2010·The American Journal of Surgical Pathology·Hiroya UeyamaSumio Watanabe
Jun 28, 2011·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hirotoshi FukatsuTakashi Yao
Apr 5, 2012·The American Journal of Surgical Pathology·Aatur D SinghiElizabeth A Montgomery
Jul 14, 2012·Journal of Gastrointestinal Cancer·Wei-Chung ChenJohn C McKechnie
Dec 11, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tetsuya UeoTetsuya Ishida
Dec 18, 2013·Endoscopy·Hiroya UeyamaSumio Watanabe
Jul 18, 2015·World Journal of Gastroenterology : WJG·Masaki MiyazawaYatsugi Noda
Jul 29, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neil D ParikhHarry Aslanian
Sep 4, 2015·Histopathology·Karen ChanM Priyanthi Kumarasinghe
Mar 11, 2016·World Journal of Gastrointestinal Endoscopy·Gen TohdaShintarou Terahata
Oct 21, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takashi ChibaDaisuke Shibuya
Sep 15, 2016·Clinical Journal of Gastroenterology·Yoshinori SatoFumio Itoh
Apr 13, 2018·American Journal of Clinical Pathology·Mark A BenedictDhanpat Jain

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Citations

Jun 18, 2020·World Journal of Clinical Cases·Cong-Cong MinHua Liu

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Methods Mentioned

BETA
dissection
biopsy

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